background: the uterus is a dynamic tissue responding to hormonal changes during reproductive cycles. as such, uterine stem cells have been studied in recent years. transcription factors oct4 and sox2 are critical for effective maintenance of pluripotent cell identity. objective: the present research evaluated the mrna expression of oct4 and sox2 in the uterine tissues of ovariectomized mice tr...

BACKGROUND Insulin resistance and hyperinsulinemia may play a role in pathogenesis of PCOS. One of the common therapeutic methods is using insulin-sensitizing drugs such as metformin and thiazolidinediones. OBJECTIVE The purpose was to determine the effect of metformin and pioglitazone on clinical, hormonal and metabolic parameters in women with PCOS. MATERIALS AND METHODS Eighty four women...

punicagranatum cv. malassaveh is one of the most desirable commercial cultivars in iran. in thisstudy some experiments were conducted to introduce the best hormonal treatments for directadventitious shoot regeneration from mentioned cultivar via cotyledonary explants. for thispurpose, both liquid and agarmurashige and skoog (1962) (ms) medium supplemented with baat 2, 4.5, 9, 13 μm alone and in...

[1] Elizari MV, Martı́nez JM, Belziti C et al. Morbidity and mortality following early administration of amiodarone in acute myocardial infarction. Eur Heart J 2000; 21: 198–205. [2] Burkart F, Pfisterer M, Kiowski W, Follath F, Burckhardt D. Effect of antiarrhythmic therapy on mortality in survivors of myocardial infarction with asymptomatic complex ventricular arrhythmias: Basel Antiarrhythmic...

Estrogens play an essential role in the normal physiology of the breast as well as in mammary tumorigenesis. Their effects are mediated by two nuclear estrogen receptors, ERα and β, which regulate transcription of specific genes by interacting with multiprotein complexes, including histone deacetylases (HDACs). During the past few years, HDACs have raised great interest as therapeutic targets i...

In vitro regeneration ability of four varieties potato (Solanum tuberosum) was evaluated for plantlet production applying hormonal concentrations and combinations. Shoot root characteristics were observed at 15 days after inoculation sprout explants. There significant variation found among the treatments in studied traits. The genotype Chollisha exhibited superior performance genotypes. Out tea...

Salinity is the major environmental factor limiting plant growth and productivity. Under salinity conditions, plant growth is affected by a number of factors such as hormonal and nutritional imbalance, ion toxicity, physiological disorders, susceptibility to diseases, etc. Plant growth under stress conditions may be enhanced by the application of microbial inoculation including plant growth pro...

Nearly all men with metastatic prostatic cancer respond to androgen ablation, demonstrating that at least a portion of their cancer cells are androgen responsive. Unfortunately, however, individual prostatic cancers contain clones of androgen-independent, in addition to androgen-responsive, cancer cells. Due to this tumor cell heterogeneity, essentially all patients treated with androgen ablati...

The estrogen receptor (ER) is implicated in the progression of breast cancer. Despite positive effects of hormonal therapy, initial or acquired resistance to endocrine therapies frequently occurs. Recent studies suggested ERa-coregulator PELP1 and growth factor receptor ErbB2/ HER2 play an essential role in hormonal therapy responsiveness. Src axis couples ERa with HER2 and PELP1, thus represen...

The treatment goal for postpartum metritis (e.g., endometritis, postpuerperal metritis, toxic puerperal metritis, pyometra) is to facilitate the timely clearance of the infection and return the animal to a normal reproductive state. Clinical signs associated with postpartum metritis range from temporary and self-limiting signs to chronic or life-threatening ones. Choosing an appropriate treatme...