High plasma homocysteine levels are a known risk factor in heart failure and sudden cardiac death. The G proteins, G(s) (stimulatory) and G(i) (inhibitory), are involved in calcium regulation; overexpression has pathological consequences. The aims of this study were to examine the differential expression of G(s) G protein and G(i) in the hearts of hyperhomocysteinemic (Hhcy) mice, and to determ...

Studies show that the aging population is at increased risk for folate deficiency, which may contribute to cognitive decline. Data reveal that with increasing age, serum and cerebrospinal fluid (CSF) folate may drop below normal levels, while serum homocysteine (Hcy), a sensitive marker of functional folate deficiency, may rise to above normal levels. The association between elevated serum Hcy ...

objective: polycystic ovary syndrome (pcos) is one of the most common endocrine disorders in women. metformin is a biguanide commonly used to improve pcos symptoms. effect of metformin on the levels of serum homocysteine (hcy) in pcos women is unclear. the aim of this study is evaluating the effect of metformin administration on serum hcy levels and metabolic parameters of pcos patients. materi...

OBJECTIVES To assess the association between plasma homocysteine (Hcy), blood pressure (BP) and poor outcome at hospital discharge among acute ischemic stroke patients, and if high Hcy increases the risk of poor outcome based on high BP status in a northern Chinese population. METHODS Between June 1, 2009 and May 31, 2013, a total of 3695 acute ischemic stroke patients were recruited from thr...

Keywords: Type 2 diabetes mellitus (T2DM) high sensitive C-reactive protein (hsCRP) Homocysteine (HCY) cardiovascular disease (CVD). Introduction: Incidence of vascular complications is found to be high in type 2 diabetes mellitus patients. Conventional risk factors were not able to explain this high prevalence of CAD. Since inflammation is considered as one of the major reasons for vascular co...

OBJECTIVE To investigate the association between total plasma homocysteine concentration, C677T and A1298C polymorphisms in MTHFR gene and Alzheimer's disease (AD) development. METHOD Forty-three patients with probable (63%) and possible (37%) AD and 50 non-demented controls were evaluated. Groups did not differ as to gender, age, scholar years, diabetes, alcohol and coffee intake and physica...

Objective: To investigate the effects of Chinese yellow wine on the synthesis of homocysteine (Hcy)-induced intracellular MMP-2 in rat vascular endothelial cells (VECs). Methods: Isolation, cultivation, purification and identification of vascular endothelial cells of rat thoracic aorta in vitro were conducted. The VECs in passages 3 to 4 were used in all studies. HCY was used to induce VECs to ...

OBJECTIVE To investigate genetic and lifestyle factors and their interactions on plasma homocysteine (Hcy) concentrations in the Boston Puerto Rican population. DESIGN Cross-sectional study. Plasma concentrations of Hcy, folate, vitamin B12 and pyridoxal phosphate were measured, and genetic polymorphisms were determined. Data on lifestyle factors were collected in interviews. SETTING A popu...

Homocysteine (Hcy) is an intermediate of methionine metabolism that, at elevated levels, is an independent risk factor for vascular disease and atherothrombosis. Patients with renal disease, who exhibit unusually high rates of cardiovascular morbidity and death, tend to be hyperhomocysteinemic, particularly as renal function declines. This observation and the inverse relationship between Hcy le...

Many human epidemiologic studies have reported associations between plasma homocysteine (Hcy) concentrations and cardiovascular disease, Alzheimer’s disease, and osteoporosis. However, few studies have examined the relationship between Hcy and disease in dogs. In this study, we investigated the relationship between canine plasma Hcy concentrations and sex, age, breed, size; spay/neuter status, ...