نتایج جستجو برای: hmgb1

تعداد نتایج: 3267  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2007
Roberta De Mori Stefania Straino Anna Di Carlo Antonella Mangoni Giulio Pompilio Roberta Palumbo Marco E Bianchi Maurizio C Capogrossi Antonia Germani

OBJECTIVE High mobility group box 1 protein (HMGB1) is a cytokine released by necrotic and inflammatory cells in response to injury. We examined the role of HMGB1 in skeletal muscle regeneration after hindlimb ischemia. METHODS AND RESULTS Unilateral hindlimb ischemia was induced in mice by femoral artery dissection. HMGB1 levels increased in regenerating skeletal muscle and the blockade of e...

2017
Kayoko Waki Kouichiro Kawano Naotake Tsuda Kimio Ushijima Kyogo Itoh Akira Yamada

High-mobility group box 1 (HMGB1) is a nuclear protein that is known to be secreted into extracellular fluids from injured cells, activated macrophages, and tumor cells. The clinical correlation of circulating HMGB1 levels with various diseases including cancer has been reported. However, there is no information on HMGB1 levels in cancer patients treated with peptide vaccination. In the present...

Journal: :International journal of molecular medicine 2007
Babett Bartling Christine Fuchs Rolf-Edgar Silber Andreas Simm

Cancer development is associated with the high mobility group box protein 1 (HMGB1), which modulates the transcriptional activity in the nucleus, but it is also present in the cytoplasm and outside the cell in certain conditions. As the progression of lung cancer is supported by mitogenic stimuli of stromal fibroblasts, we studied the impact of lung fibroblasts (WI-38) on the expression and loc...

2014
Noriyuki Kuroda Kouji Inoue Tadayuki Ikeda Yaiko Hara Kenjiro Wake Tetsuji Sato

HMGB1 is a nuclear component involved in nucleosome stabilization and transcription regulation, but extracellularly it is able to serve as a potential late mediator of lethality. In the present study, we explored inflammation-promoting activity of HMGB1 and blockade of extracellular release of HMGB1 by glycyrrhizin (GL) in LPS/GalN-triggered mouse liver injury. At 1 to 10 h after LPS/GalN-treat...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Anna Bangert Martin Andrassy Anna-Maria Müller Mariella Bockstahler Andrea Fischer Christian H Volz Christoph Leib Stefan Göser Sevil Korkmaz-Icöz Stefan Zittrich Andreas Jungmann Felix Lasitschka Gabriele Pfitzer Oliver J Müller Hugo A Katus Ziya Kaya

Autoimmune response to cardiac troponin I (TnI) induces inflammation and fibrosis in the myocardium. High-mobility group box 1 (HMGB1) is a multifunctional protein that exerts proinflammatory activity by mainly binding to receptor for advanced glycation end products (RAGE). The involvement of the HMGB1-RAGE axis in the pathogenesis of inflammatory cardiomyopathy is yet not fully understood. Usi...

Journal: :Acta medica Okayama 2009
Hidenori Wake Shuji Mori Keyue Liu Hideo K Takahashi Masahiro Nishibori

Angiogenesis involves complex processes mediated by several factors and is associated with inflammation and wound healing. High mobility group box 1 (HMGB1) is released from necrotic cells as well as macrophages and plays proinflammatory roles. In the present study, we examined whether HMGB1 would exhibit angiogenic activity in a matrigel plug assay in mice. HMGB1 in combination with heparin st...

2015
Diana Zabini Slaven Crnkovic Hui Xu Maria Tscherner Bahil Ghanim Walter Klepetko Andrea Olschewski Grazyna Kwapiszewska Leigh M Marsh

Extracellular high-mobility group box-1 (HMGB1) acts as a signalling molecule during inflammation, cell differentiation and angiogenesis. Increased abundance of HMGB1 is associated with several pathological disorders such as cancer, asthma and chronic obstructive pulmonary disease (COPD). In this study, we investigated the relevance of HMGB1 in the pathological remodelling present in patients w...

Journal: :Blood 2011
Jong-Sup Bae Alireza R Rezaie

A pathogenic role for high-mobility group box 1 (HMGB1) protein has been postulated in severe sepsis. Activated protein C (APC) is the only drug approved by the Food and Drug Administration for severe sepsis; however, its effect on HMGB1 signaling has never been investigated. Here, we monitored the effect of APC on the lipopolysaccharide-mediated release of HMGB1 and the HMGB1-mediated modulati...

Journal: :Molecular and cellular biology 2007
Noboru Taniguchi Kenji Yoshida Tatsuo Ito Masanao Tsuda Yasunori Mishima Takayuki Furumatsu Lorenza Ronfani Kazuhiro Abeyama Ko-ichi Kawahara Setsuro Komiya Ikuro Maruyama Martin Lotz Marco E Bianchi Hiroshi Asahara

High mobility group box 1 protein (HMGB1) is a chromatin protein that has a dual function as a nuclear factor and as an extracellular factor. Extracellular HMGB1 released by damaged cells acts as a chemoattractant, as well as a proinflammatory cytokine, suggesting that HMGB1 is tightly connected to the process of tissue organization. However, the role of HMGB1 in bone and cartilage that undergo...

2017
Shuang Jiang Xiaolong Chen

BACKGROUND Diabetic retinopathy (DR), one of the most common complications of late-phase diabetes, is associated with many risk factors, among which continuous low-grade inflammation is one of the principal ones. As such, lowering inflammation levels and maintain the viability of human retinal endothelial cells (HRECs) are critical for DR therapy. HMGB1 is a well-known proinflammatory cytokine....

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید