Context: Hepatitis C Virus (HCV) infection is a major cause of chronic cirrhosis and hepatocellular carcinoma. Approximately 30% infected persons with HCV spontaneously clear the viral infection; but, some remaining patients develop HCV. Studies show that HLA molecules play an important role in outcome by influencing efficiency antiviral immune response to infection. It now known polymorphisms ...

  Background and Objective: The outcome of hepatitis B virus (HBV) infection may be influenced by host factors like Human Leukocyte Antigen (HLA). We have investigated HLA-A and DRB1 alleles in patients with persistent hepatitis B infection compared to subjects who had spontaneously recovered from HBV infection. To complete the findings of this study we performed another survey in certain HLA ...

Objective(s): This study aimed to investigate the association between human leukocyte antigen Cw (HLA-Cw) polymorphisms and rheumatoid arthritis (RA) in Chinese Han patients in the Jiangsu area (Southern China).Materials and Methods: Polymerase chain reaction-sequence specific primers were used to detect HLA-Cw01–08 of 201 RA patients an...

BackgroundIn patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated specific clinical phenotypes suggesting a pathogenic role of adaptive immunity. We explored if autoantibody profiles HLA genetic variants and manifestations in IIM.MethodsWe included 1348 IIM determined the occurrence 14 myositis-specific or –associated autoantibodies. used unsupervised cluster an...

Abstract Immunotherapeutic approaches in cancer aim to booster T cell mediated immune responses. Tumor-specific cells recognize target via human leukocyte antigen (HLA) molecules before specific lysis is initiated. Malignant gliomas are known for their immunoevasive and immunosuppressive properties which impede effective tumor-specific responses, including clinical responses checkpoint inhibiti...

Received 26/5/2009 Accepted 24/3/2010 (004215) 1 Departamento de Ciência de Alimentos, Faculdade de Engenharia de Alimentos – FEA/DCA, Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brasil 2 Departamento de Química e Bioquímica, Instituto de Biociências de Botucatu – IBB/DQB, Universidade Estadual Paulista “Júlio de Mesquita Filho” UNESP, Distrito de Rubião Jr., s/n, CEP 18618-970, Bo...