نتایج جستجو برای: hla dq b1

تعداد نتایج: 61570  

ژورنال: :آزمایشگاه و تشخیص 0
سمیه نجفی somayeh najafi islamic azad university, tonekabon branch, tonekabon, iranدانشگاه آزاد واحد تنکابن، تنکابن، ایران علی ناظمی ali nazemi department of biology, islamic azad university, tonekabon branch, tonekabon, iranدانشگاه آزاد واحد تنکابن، تنکابن، ایران

کمپلکس اصلی سازگاری بافتی(mhc)، یک قسمت از ژنوم است که نقش اساسی در بروز پاسخ ایمنی نسبت به آنتی ژن های پروتئینی ایفا می کنند و در بازوی کوتاه کروموزوم 6 واقع شده است که در انسان این کمپلکس را تحت عنوان آنتی ژن های لکوسیتی انسان (hla) می شناسند. hla بر اساس ساختمان توزیع بافتی و عملکرد به سه ناحیه مشخص کلاس i (دارای جایگاه a، b و c)، hla کلاس ii (dr, dq, dp)  و کلاس iii تقسیم می شود. بررسی های ...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1992
L M Pottern J J Gart J M Nam G Dunston J Wilson R Greenberg J Schoenberg G M Swanson J Liff A G Schwartz

To evaluate the possibility that genetic factors contribute to the excess rates of multiple myeloma among blacks, serological typing of human leukocyte antigens (HLA) was conducted for black and white male patients and controls who participated in a large population-based case-control interview study. Forty-six black cases, 88 black controls, 85 white cases, and 122 white controls were typed fo...

Journal: :Acta medica Okayama 1994
H Nishimoto G Yamada M Mizuno T Tsuji

We studied the distribution of class 1 and class 2 major histocompatibility complex (MHC) antigens on bile duct epithelial cells in liver from patients with primary biliary cirrhosis (PBC) by an immunohistochemical method using monoclonal antibodies to HLA-ABC products and HLA-D subregion products (HLA-DR, -DP, -DQ). By light microscopy, the expression of MHC class 1 antigens (HLA-ABC antigens)...

Journal: :The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2017
Hakim Rahmoune Nada Boutrid Mounira Amrane Belkacem Bioud

The major histocompatibility complex (MHC) is located on chromosome 6 and includes more than 200 genes, most of which such as those encoding HLA are a mandatory requisite for the immune system. In particular, the HLA class II genomic region encodes proteins (namely HLA DR, DQ, and DP) involved in the presentation of extracellular peptides to HLA class II T helper cells (Thelper) that mediates t...

Journal: :Journal of leukocyte biology 1993
A E Woolfrey L C Andersen L Shewey J Chung G T Nepom

Class II major histocompatibility complex genes are differentially expressed during cellular activation and differentiation, often in a locus-specific manner. We investigated the differential expression of the HLA-DQB gene, using B cell lines LAZ221 and LAZ388: LAZ221, derived from an early B cell leukemia, expresses HLA-DR but not HLA-DQ: LAZ388, the autologous Epstein-Barr virus-transformed B...

2016
Lucas Malta Almeida Lenora Gandolfi Riccardo Pratesi Rosa Harumi Uenishi Fernanda Coutinho de Almeida Nicole Selleski Yanna Karla de Medeiros Nóbrega

Background. Celiac disease (CD) is a genetically determined immune-mediated disorder in which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5, DQ8, DQ2.2, and their combinations. Our aim is to establish a risk gradient for celiac disease based on HLA-DQ profile in a brazilian representative population and the relevance of DQ2.2 in celiac disease development. Materials and ...

2013
Cao Nguyen Michael D. Varney Leonard C. Harrison Grant Morahan

Evaluating risk of developing type 1 diabetes (T1D) depends on determining an individual's HLA type, especially of the HLA DRB1 and DQB1 alleles. Individuals positive for HLA-DRB1*03 (DR3) or HLA-DRB1*04 (DR4) with DQB1*03:02 (DQ8) have the highest risk of developing T1D. Currently, HLA typing methods are relatively expensive and time consuming. We sought to determine the minimum number of sing...

Journal: :Arthritis and rheumatism 2004
Floris A van Gaalen Jill van Aken Tom W J Huizinga Geziena M Th Schreuder Ferdinand C Breedveld Eric Zanelli Walther J van Venrooij Cornelis L Verweij René E M Toes René R P de Vries

OBJECTIVE The functional role of HLA class II molecules in the pathogenesis of rheumatoid arthritis (RA) is unclear. HLA class II molecules are involved in the interaction between T and B lymphocytes required for long-lived B cell responses and generation of high-affinity IgG antibodies. We undertook this study to investigate the relationship between HLA class II gene polymorphisms and RA-speci...

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