The Histone Database is a curated and searchable collection of full-length sequences and structures of histones and nonhistone proteins containing histone-like folds, compiled from major public databases. Several new histone fold-containing proteins have been identified, including the huntingtin-interacting protein HYPM. Additionally, based on the recent crystal structure of the Son of Sevenles...

Four kinds of rabbit thymus H1 histone differ among themselves in their ability to retain DNA on nitrocellulose filters. This is true for linear, or superhelical DNA, but the order of effectiveness of the different H1 histones depends on the physical conformation of the DNA. For linear DNA the binding efficiencies of the H1 histones are: RTL2 = RTL3 greater than RTL4 greater than RTL1. This ord...

Histones are widely believed to carry regulatory information across cell generations. A recent study suggests limits to this model by measuring dispersal of ancestral histones in yeast.

Archaeal histone-encoding genes have been identified in marine Crenarchaea. The protein encoded by a representative of these genes, synthesized in vitro and expressed in Escherichia coli, binds DNA and forms complexes with properties typical of an archaeal histone. The discovery of histones in Crenarchaea supports the argument that histones evolved before the divergence of Archaea and Eukarya.

Abstract Respiratory disease in several species can range from subclinical infection to acute death. Bovine respiratory (BRD) remains the greatest economic challenge facing beef industry. Histones are core proteins chromosomal structure that, when released extracellularly, cytotoxic and could contribute exacerbated tissue necrosis during infection. Work our laboratory demonstrated cattle suffer...

The uptake and clearance of apoptotic cells by macrophages and other phagocytic cells, a process called efferocytosis, is a major component in the resolution of inflammation. Increased concentrations of extracellular histones are found during acute inflammatory states and appear to contribute to organ system dysfunction and mortality. In these studies, we examined the potential role of histones...

Physarumpolycephalum is an acellular slime mould whose histones are of general interest because they allow comparisons to be made between lower eukaryote and higher eukaryote histones and, perhaps more importantly, they provide a unique opportunity for the study of histone changes in the mitotic cycle, which is naturally synchronous in P. polycephalum plasmodia, and during differentiation. Stud...

Ubiquitination & Sumoylation C e l l C y c l e & D N A T r a n s a c t i o n s In eukaryotes, the several meters long genomic DNA needs to be packed into chromosomes with a diameter of only several hundred micrometers. This is achieved through an elaborated scheme of packaging that starts with the formation of nucleosomes from DNA winding around an octamer core of histones H2A/H2B/H3/H4, foll...