نتایج جستجو برای: histone h1

تعداد نتایج: 54763  

Journal: :Journal of immunology 2009
Kuei-Chen Chiang Yayoi Shimada Toshiaki Nakano Chia-Yun Lai Li-Wen Hsu Shigeru Goto Naoya Ohmori Kenji Mori Takamitsu Miyagi Seiji Kawamoto Kazuhisa Ono Chao-Long Chen Takeshi Goto Shuji Sato

We reported that anti-histone H1 autoantibody is one of the main immunosuppressive factors in serum that is induced after orthotopic liver transplantation in a rat tolerogenic model. We generated a novel anti-histone H1 IgM mAb produced by hybridoma 16G9 (16G9 mAb) that shows MLR-inhibitory activity. Identification of a functional epitope responsible for the immunosuppressive activity of 16G9 m...

2012
Yunzhe Zhang Zheng Liu Magdalena Medrzycki Kaixiang Cao Yuhong Fan

The evolutionarily conserved homeotic (Hox) genes are organized in clusters and expressed collinearly to specify body patterning during embryonic development. Chromatin reorganization and decompaction are intimately connected with Hox gene activation. Linker histone H1 plays a key role in facilitating folding of higher order chromatin structure. Previous studies have shown that deletion of thre...

Journal: :Journal of cell science 1991
A L Symington S Zimmerman J Stein G Stein A M Zimmerman

Exposure of HeLa S3 cells to high hydrostatic pressure (6.89 x 10(3) to 6.89 x 10(4) kPa: 1000 to 10,000 lbfin-2) reduced core and H1 histone mRNA levels as determined by hybridization to specific histone DNA probes. At 4.14 x 10(4) kPa for 10 min core histone and H1 histone mRNA levels were reduced 32-38% and 56%, respectively. At 30 min postdecompression core mRNA levels returned to atmospher...

Journal: :Cell 1995
Xuetong Shen Lanlan Yu Joyce W. Weir Martin A. Gorovsky

We have (separately) disrupted all of the expressed macronuclear copies of the HHO gene encoding macronuclear histone H1 and of the micronuclear linker histone (MLH) gene encoding the protein MicLH in Tetrahymena thermophila. These disruptions are shown to eliminate completely the expression of each protein. Strains without either linker histone grow at normal rates and reach near-normal cell d...

2006
Elisavet Koutzamani

POPULÄRVETENSKAPLIG SAMMANFATTNING LIST OF PUBLICATIONS LIST OF ABBREVIATIONS INTRODUCTION 15 Chromatin History and Research 16 Nobel Prizes Related to Chromatin 19 AIMS OF THE STUDY 21 CHROMATIN STRUCTURE 23 DNA 23 Composition of DNA 23 The Nucleosome 26 Location of Linker Histones 27 Higher-Order Chromatin Structure 28 Euchromatin and Heterochromatin 30 THE HISTONES 31 Histone Variants 32 Cor...

Journal: :The Journal of biological chemistry 1986
H Yasuda R D Mueller K A Logan E M Bradbury

An antiserum specific for the globular domain of the bovine very lysine-rich histone subfraction H1(0) cross-reacted with a single protein band in the chromosomal proteins isolated from microplasmodia of the true slime mold Physarum polycephalum. Its amino acid composition was characteristic of a very lysine-rich histone which supported its identification as Physarum H1(0). Unlike Physarum H1(0...

Journal: :The Journal of biological chemistry 1979
D Ring R D Cole

When whole steer kidney nuclei were treated with dimethyl-3,3'-dithiobisproprionimidate, N,N'-bis(2-carboxyimidomethyl) tartaramide dimethyl ester, or 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide under approximately physiological ionic conditions, H1 histone was cross-linked to each of the four histones in the nucleosome core. The carbodiimide reagent, which introduces no atoms between the am...

Journal: :EMBO reports 2002
Frédéric Catez David T Brown Tom Misteli Michael Bustin

The ability of regulatory factors to access their nucleosomal targets is modulated by nuclear proteins such as histone H1 and HMGN (previously named HMG-14/-17 family) that bind to nucleosomes and either stabilize or destabilize the higher-order chromatin structure. We tested whether HMGN proteins affect the interaction of histone H1 with chromatin. Using microinjection into living cells expres...

Journal: :Cell 2005
Yuhong Fan Tatiana Nikitina Jie Zhao Tomara J. Fleury Riddhi Bhattacharyya Eric E. Bouhassira Arnold Stein Christopher L. Woodcock Arthur I. Skoultchi

Linker histone H1 plays an important role in chromatin folding in vitro. To study the role of H1 in vivo, mouse embryonic stem cells null for three H1 genes were derived and were found to have 50% of the normal level of H1. H1 depletion caused dramatic chromatin structure changes, including decreased global nucleosome spacing, reduced local chromatin compaction, and decreases in certain core hi...

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