A major challenge in automatic registration, alignment and 3-D reconstruction of conventionally processed mouse brain slice images is the presence of histological artifacts, like tissue tears and losses. These artifacts are often produced from manual sample preparation processes, which are ubiquitous in most neuroanatomical laboratories. We present a novel geometric algorithm to automatically d...

Honey, containing mainly fructose and glucose, is either taken as curative agent or substitute for refined sugar, yet its chronic effect on liver morphology has not been reported. This study reports an investigation into the histological changes in adult Wistar rats exposed to chronic consumption of honey. Twenty adult Wistar rats (170 200 grams) were divided into four groups of five rats each....

AIMS To study the oesophageal histological changes in long term users of non-steroidal anti-inflammatory drugs (NSAIDs) compared with patients not receiving these drugs. METHODS Ninety eight patients were studied, 53 of whom had taken NSAIDs for three years; 45 had not. Oesophageal biopsy specimens were taken from healthy-looking mucosa in the lower third of oesophagus. The papillary length, ...

BACKGROUND Impaired blood flow below certain critical levels and an insufficient supply of energy-rich substrates cause failure of neuronal function, triggering biochemical disturbances that eventually lead to ischemic cell damage. SUMMARY OF REVIEW This article reviews experimental studies that attempted to define those ischemic thresholds using functional and histological markers and, more ...

We perform subsurface ablation of atherosclerotic plaque using ultrafast pulses. Excised mouse aortas containing atherosclerotic plaque were ablated with ultrafast near-infrared (NIR) laser pulses. Optical coherence tomography (OCT) was used to observe the ablation result, while the physical damage was inspected in histological sections. We characterize the effects of incident pulse energy on s...

Repetitive exposure to short laser pulses is shown to cause selective damage to absorbing structures (cells, organelles, or enzymes) with pulse energies below the threshold energy for single-pulse damage. Directly adjacent structures are spared in vivo. Additivity of (presumably nonphotochemical) subthreshold effects is demonstrated. Selective damage to the retinal pigment epithelium with spari...

Background: Impaired blood flow below certain critical levels and an insufficient supply of energy-rich substrates cause failure of neuronal function, triggering biochemical disturbances that eventually lead to ischemic cell damage. Summary of Review: This article reviews experimental studies that attempted to define those ischemic thresholds using functional and histological markers and, more ...

background and aims. mineral trioxide aggregate and calcium hydroxide are considered the gold standard pulp-capping materials. recently, portland cement has been introduced with properties similar to those of mineral trioxide aggregate. histopathological effects of direct pulp capping using mineral trioxide aggregate and portland cements on dog dental pulp tissue were evaluated in the present s...

there is an impression that basal cell carcinomas (bcc) occurring in younger population may be of more invasive behavior in comparison to those arising in older patients. the purpose of this study was to investigate this hypothesis by comparing the histological types of bcc in a large cohort of young and old patients. a total of 287 histological reports and clinical records were evaluated. a co...