نتایج جستجو برای: histaminergic neurons

تعداد نتایج: 169747  

2017
Bejan Aresh Fabio B. Freitag Sharn Perry Edda Blümel Joey Lau Marina C.M. Franck Malin C. Lagerström

Itch is a sensation that promotes the desire to scratch, which can be evoked by mechanical and chemical stimuli. In the spinal cord, neurons expressing the gastrin-releasing peptide receptor (GRPR) have been identified as specific mediators of itch. However, our understanding of the GRPR population in the spinal cord, and thus how these neurons exercise their functions, is limited. For this pur...

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2011
Cristiano André Köhler Weber Cláudio da Silva Fernando Benetti Juliana Sartori Bonini

Encoding for several memory types requires neural changes and the activity of distinct regions across the brain. These areas receive broad projections originating in nuclei located in the brainstem which are capable of modulating the activity of a particular area. The histaminergic system is one of the major modulatory systems, and it regulates basic homeostatic and higher functions including a...

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Journal: :The Journal of pharmacology and experimental therapeutics 2007
X Ligneau D Perrin L Landais J-C Camelin T P G Calmels I Berrebi-Bertrand J-M Lecomte R Parmentier C Anaclet J-S Lin V Bertaina-Anglade C Drieu la Rochelle F d'Aniello A Rouleau F Gbahou J-M Arrang C R Ganellin H Stark W Schunack J-C Schwartz

Histamine H3 receptor inverse agonists are known to enhance the activity of histaminergic neurons in brain and thereby promote vigilance and cognition. 1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride (BF2.649) is a novel, potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor. On the stimulation of guanosine 5'-O-(3-[35S]thio)triphosphate bindin...

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Journal: :Neuroscience letters 2011
Ivana Marasović-Šušnjara Vinko Palada Ivana Marinović-Terzić Ninoslav Mimica Josipa Marin Dorotea Muck-Seler Maja Mustapić Paola Presečki Nela Pivac Vera Folnegović-Šmalc Jasna Marinović-Ćurin Janoš Terzić

Several abnormalities, including lower histamine levels in brain, elevated serum histamine and degeneration of histaminergic neurons in tuberomammillary nucleus, were described in the histaminergic system of patients with Alzheimer's disease (AD). Histamine is a central neurotransmitter with several functions in brain including regulation of memory, cognition, locomotion, and is degraded in par...

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2013
Henri A. J. Puttonen Maria Sundvik Stanislav Rozov Yu-Chia Chen Pertti Panula

Earlier studies in zebrafish have revealed that acutely given ethanol has a stimulatory effect on locomotion in fish larvae but the mechanism of this effect has not been revealed. We studied the effects of ethanol concentrations between 0.75 and 3.00% on 7-day-old larval zebrafish (Danio rerio) of the Turku strain. At 0.75-3% concentrations ethanol increased swimming speed during the first minu...

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Journal: :Indian journal of physiology and pharmacology 1984
P P Singh A Y Junnarkar M U Naidu R K Varma R M Tripathi D R Shridhar

Clonidine is reported to inhibit the az-adrenoceptor mediated pinnal reflex in mice (3). Clonidine produces its effect by acting as an oc2-adrenergic autoreceptor agonist (1). As such, clonidine is also agonist for presynaptic histamine Hz-receptors (8). To test whether the clonidine-induced inhibition of the pinnal reflex is mediated through adrenergic and/or histaminergic system, the interact...

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2011
Mamoru TANIDA Katsuya NAGAI

Autonomic nerves, consisting of both sympathetic and parasympathetic nerves, regulate various bodily functions such as blood pressure, body temperature, glucose metabolism, energy metabolism, and digestion. Our studies in rats and mice have demonstrated that food, flavor, and music affect physiological phenomena via changes in autonomic neurotransmissions. Intestinal injection of Lactobacillus ...

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Journal: :Neuroscience Letters 2014

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Journal: :Acta dermato-venereologica 2015
Hjalte H Andersen Jesper Elberling Lars Arendt-Nielsen

Within the last decade understanding of the mechanistic basis of itch has improved significantly, resulting in the development of several human surrogate models of itch and related dysesthetic states. Well-characterized somatosensory models are useful in basic studies in healthy volunteers, in clinical studies for diagnostic and segmentation purposes, and in pharmacological studies to evaluate ...

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2017
Hjalte Holm

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