Rhp14 of Schizosaccharomyces pombe is homologous to human XPA and Saccharomyces cerevisiae Rad14, which act in nucleotide excision repair of DNA damages induced by ultraviolet light and chemical agents. Cells with disrupted rhp14 were highly sensitive to ultraviolet light, and epistasis analysis with swi10 (nucleotide excision repair) and rad2 (Uve1-dependent ultraviolet light damage repair pat...

Leptospirosis is a worldwide zoonosis caused by pathogenic Leptospira. The whole-genome sequence of L. interrogans serovar Copenhageni together with bioinformatics tools represent a great opportunity to search for novel antigen candidates that could be used as subunit vaccine against leptospirosis. We focused on six genes encoding for conserved hypothetical proteins predicted to be exported to ...

Intracellular delivery of functional macromolecules using peptide transduction domains (PTDs) is an exciting technology with both experimental and therapeutic applications. Recent data indicate that PTD-mediated transduction occurs via fluid-phase macropinocytosis involving an intracellular pH drop to approximately 5. Nitrilotriacetic acid (NTA)-coordinated metals avidly bind hexahistidine-tagg...

To my beloved wife Fatma for her patience, encouragement, and support and To my daughter Ayse and son Omer. ii ACKNOWLEDGMENTS First and foremost, I would like to express my special gratitude to my advisor Dr. support over the past four years. He made the last four tough years of my Ph.D. studies and research fun with his friendship and humor. I am deeply grateful to him for always being there ...

Research on familiar face recognition has largely focused on the neural correlates of recognizing a beloved partner or family member. However, no research has explored the effect of marriage style on the recognition of a beloved partner's face, especially in matriarchal societies. Here, we examined the time course of event-related potentials (ERP) in response to the face of a beloved partner, s...

The story of Abraham’s willingness to give up his beloved son (Gen. 22) is a highly productive text – that is, it has triggered subsequent literary activity and played significant role in the composition shaping other texts. In this essay, I want first explore possibility 1 Kgs 17–18 yet another which an author alluded Gen. 22 then reflect on use as source for narratives composed analogies it.

William Shakespeare’s play Othello features the life of Othello, a black Moor, Muslim, who although is most trusted man King Venice, struggles to fit in with prominent White, Christian medieval framework Venice. He indirectly subscribes prevailing morality and thinks himself inferior rich, white European Christians. tries be like them, imbibing their values codes, but still his different color ...