Abstract Purpose Liver transplantation (LT) has gained ground as a treatment for cholangiocarcinoma. LT achieved an established role curative unresectable hilar cholangiocarcinoma (hCCA), and there are emerging data supporting its use in select patients with intrahepatic (iCCA). This review explores the current frontiers future directions of CCA. Recent Findings Results retrospective studies su...

The role of autophagy in cholangiocarcinoma is poorly understood. This study investigated its involvement in cholangiocarcinoma, focusing on carcinoma cell invasion and prognostic significance using cholangiocarcinoma cell lines, CCKS1 and HuCCT1, and human tissues of hilar and extrahepatic cholangiocarcinoma. Nutrient starvation induced the expression of LC3-II and the formation of LC3 puncta ...

In patients with inoperable hilar cholangiocarcinoma (HCCA), palliative endoscopic or percutaneous drainage provides benefits in terms of symptomatic improvement and quality of life. Endoscopic biliary stent placement is considered the gold standard, with metal stents preferred over plastic stents in patients with more than three months of life expectancy. However, the endoscopic management of ...

The incidence of cholangiocarcinoma is increasing worldwide. Patients present with abdominal pain, whereas weight loss and malaise are symptoms advanced disease. Jaundice occurs when there hilar obstruction by the tumor. Surgical management involves resection affected hepatic segments or liver transplantation, which requires a dedicated multidisciplinary team approach, promising outcomes seen i...