opal UGA stop codon, whereas in the eukaryotes, it is the ochre UAA stop codon. Viruses reassigned the ochre UAA or amber UAG stop codons. The largest number of recoding events appeared in a sulfidic groundwater sample and in the human oral microbiome. In an artful use of reassignment, it appears that some phages use codon reassignment to hijack the host machinery to begin translate their own s...

Hallmarks of Yersinia pathogenesis include the ability to form biofilms on surfaces, the ability to establish close contact with eukaryotic target cells and the ability to hijack eukaryotic cell signaling and take over control of strategic cellular processes. Many of these virulence traits are already well-described. However, of equal importance is knowledge of both confined and global regulato...

B and T lymphocytes recognize antigens with high specificity, but neither initiate immune responses, nor decide their types. These functions rest upon dendritic cells (DCs), which can determine and maintain Th1/Th2 polarization. Immune responses are thus dependent on the DC subset, the receptors that recognize each pathogen and the microenvironment. Microbes employ an array of mechanisms to eva...

This paper introduces the compelled certificate creation attack, in which government agencies may compel a certificate authority to issue false SSL certificates that can be used by intelligence agencies to covertly intercept and hijack individuals’ secure Web-based communications. Although we do not have direct evidence that this form of active surveillance is taking place in the wild, we show ...

To efficiently bud off from infected cells, HIV and other enveloped viruses hijack the host cellular machinery that is normally involved in vacuolar protein sorting and multivesicular body (MVB) biogenesis. The HIV Gag protein mimics hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs), a modular adaptor protein that links membrane cargo recognition to its degradation after delive...

Gene associated with retinoid-interferon-β-induced mortality (GRIM)-19, was originally identified as a critical regulatory protein necessary for Interferon-β-Retinoic acid-induced cell death. Overexpression of GRIM-19 activates cell death and its suppression or inactivation promotes cell growth. GRIM-19 targets multiple proteins/pathways for exerting growth control and cell death. However, GRIM...

Productive replication of DNA viruses elicits host cell DNA damage responses, which cause both beneficial and detrimental effects on viral replication. In response to the viral productive replication, host cells attempt to attenuate the S-phase cyclin-dependent kinase (CDK) activities to inhibit viral replication. However, accumulating evidence regarding interactions between viral factors and c...

Wnt signalling regulates several cellular functions including proliferation, differentiation, apoptosis and migration, and is critical for embryonic development. Stem cells are defined by their ability for self-renewal and the ability to be able to give rise to differentiated progeny. Consequently, they are essential for the homeostasis of many organs including the gastrointestinal tract. This ...

REpresentational State Transfer (REST) guided the creation and expansion of the modern web. What began as an internet-scale distributed hypermedia system is now a vast sea of shared and interdependent services. However, proposed Web Services protocols abandon REST altogether in favor of SOAP (Simple Object Access Protocol) exchanges codified in XML that hijack HTTP (HyperText Transport Protocol...

During viral infection the first challenge that viruses have to overcome is gaining access to the intracellular compartment. The infection process starts when the virus contacts the surface of the host cell. A complex series of events ensues, including diffusion at the host cell membrane surface, binding to receptors, signaling, internalization, and delivery of the genetic information. The focu...