BACKGROUND High-sensitivity cardiac troponin assays will augment the frequency of increased results, making important the determination of reference change values to distinguish acute from chronic increases. We assessed short- and long-term biological variability of cardiac troponin T (cTnT) in healthy subjects with a novel high-sensitivity (hs) assay. METHODS We collected blood from 20 healt...

Penyakit kardiovaskular masih menjadi ancaman yang menakutkan bagi bangsa Indonesia. Kematian terjadi di Indonesia akibat dari penyakit sangat tinggi dimana sindroma koroner akut (SKA) termasuk dalamnya. High sensitive troponin I (hs-cTnI) merupakan biomarka spesifik dalam mendeteksi adanya kerusakan miokardium dan berhubungan dengan peningkatan risiko Major Adverse Cardiovascular Events (MACE)...

Myocardial ischemia is characterized by reduced blood flow to cardiomyocytes, which can lead to acidosis. Acidosis decreases the calcium sensitivity and contractile efficiency of cardiac muscle. By contrast, skeletal and neonatal muscles are much less sensitive to changes in pH. The pH sensitivity of cardiac muscle can be reduced by replacing cardiac troponin I with its skeletal or neonatal cou...

inflammatory basis in pathopoiesis of coronary artery disease (cad) have been demonstrated in recent decades. elevated c-reactive protein (crp) and leukocytosis were associated with an elevated risk   for acute coronary syndrome (acs). to evaluate the relationship between quantitative crp and cardiac troponin i in conjunction with white blood cell (wbc) count and 30 days outcomes and treatment ...

AIMS To assess the role of cardiac troponin T (cTnT) levels on admission using a new, highly sensitive assay (hsTnT) in the risk assessment of normotensive patients with acute pulmonary embolism (PE). METHODS AND RESULTS We prospectively studied 156 consecutive normotensive patients with confirmed PE. The prognostic value of hsTnT at baseline was compared with the conventional cTnT troponin a...

Sir, M of myocardial necrosis have gone through a long journey since 1950s.The cardiac biomarkers(CB) of past include total creatine kinase (CK) activity, aspartate aminotransferace activity (AST), lactate dehydrogenase (LDH) and LD1/LD2 ratio while the current CB are CK-MB, myoglobin, CKMB isoforms, cardiac troponin (cTn) I and T. The introduction of heart –type fatty–acid binding protein (H-F...