Motivation: Chromatin Interaction Analysis by Paired-End Tag sequencing (ChIA-PET) is an established method for detecting genome-wide looping interactions at high resolution. Current ChIA-PET analysis software packages either fail to correct for non-specific interactions due to genomic proximity or only address a fraction of the steps required for data processing. We present Mango, a complete C...

Stanford University, USA A time-of-flight (TOF)-PET/MR research system installed at Stanford will be used to test the hypotheses that (a) it is possible to acquire simultaneous TOF-PET and 3T MR data while achieving uncompromised performance in both modalities and (b) simultaneous TOF-PET/MR is a tool for multi-parameter characterization of disease. In this paper we will describe the design as ...

The main thrust for this work is the investigation and design of a whole-body PET scanner based on new lanthanum bromide scintillators. We use Monte Carlo simulations to generate data for a 3D PET scanner based on LaBr3 detectors, and to assess the count-rate capability and the reconstructed image quality of phantoms with hot and cold spheres using contrast and noise parameters. Previously we h...

intractable asthma is a challenging clinical problem. this study was conducted to determine whether a subset of patients with intractable asthma may be misdiagnosed and have a form of bronchiolitis instead and also to determine the effectiveness of macrolide therapy in these patients. seventy six patients with intractable asthma were re-treated with recommended maximal doses of oral prednisolon...

MOTIVATION Chromatin Interaction Analysis by Paired-End Tag sequencing (ChIA-PET) is an established method for detecting genome-wide looping interactions at high resolution. Current ChIA-PET analysis software packages either fail to correct for non-specific interactions due to genomic proximity or only address a fraction of the steps required for data processing. We present Mango, a complete Ch...

A prototype time-of-flight (TOF) PET scanner based on cerium-doped lanthanum bromide [LaBr(3) (5% Ce)] has been developed. LaBr(3) has a high light output, excellent energy resolution and fast timing properties that have been predicted to lead to good image quality. Intrinsic performance measurements of spatial resolution, sensitivity and scatter fraction demonstrate good conventional PET perfo...

Positron emission tomography (PET) is a molecular imaging method that images the human body non-invasively from a functional, biochemical perspective. PET is extraordinarily sensitive and can detect minute (femtomolar) quantities of radioactive tracers. However, because of photon scattering, the images do not have as high spatial resolution as CT or MRI nor do they provide much anatomical infor...

OBJECTIVE PET using semiconductor detectors provides high-quality images of the human brain because of its high spatial resolution. To quantitatively evaluate the delineation of image details in clinical PET images, we used normalized mutual information (NMI) to quantify the similarity with images obtained through MRI. NMI is used to evaluate image quality by determining similarity with a refer...