PURPOSE To investigate the expression of αA- and αB-crystallin and the unfolded protein response in the lens epithelium of patients with high myopia-related cataracts. METHODS AND MATERIALS The central portion of the human anterior lens capsule together with the adhering epithelial cells, approximately 5 mm in diameter, were harvested and processed within two hours after cataract surgery from...

Background: Myopia has different prevalence rate worldwide and there is controversial points about its environmental risk factors. The prevalence of myopia in medical interns atShirazMedicalSchool and its probable risk factors were studied. Method: In this retrospective cross-sectional study, three hundred interns (7th-year medical students) at Shiraz University of Medical Sciences were examine...

PURPOSE Three previous studies have tested for an association between high myopia and polymorphisms in the open angle glaucoma gene, myocilin (MYOC), all in subjects of Chinese ethnicity. In two of the studies, a significant association was found while in the third, there was no association. We sought to investigate the association between high myopia and polymorphisms in MYOC in subjects of Eu...

PURPOSE Despite the plethora of experimental myopia animal studies that demonstrate biochemical factor changes in various eye tissues, and limited human studies utilizing pharmacologic agents to thwart axial elongation, we have little knowledge of the basic physiology that drives myopic development. Identifying the implicated genes for myopia susceptibility will provide a fundamental molecular ...

Acute myopia following use of some drugs is a relatively rare condition. Topiramate prescribed for seizure prophylaxis is one of these drugs. In this paper a case of acute transient myopia after taking topiramate is reported. The reported patient is a 28-year old woman who had no history of any eye disease. Following consumption of topiramate pill for one week, she had found blurred vision ...

PURPOSE The purpose of this study was to determine if genetic variants in the hepatocyte growth factor receptor (MET) gene are associated with refractive error and ocular biometric measures in a Caucasian cohort. METHODS A case-control association study using 818 Caucasian adults (37.2% male, 62.8% female; average age: 51.21+/-17.17 years) was undertaken. All individuals were genotyped for 16...

OBJECTIVE To investigate the genetic association between transforming growth factor beta1 (TGFB1) gene polymorphisms and high myopia in a Chinese population. METHODS Six hundred adults were recruited for this case-control study, including 300 subjects with high myopia (-8.0 diopters or worse) and 300 control subjects (within +/-1.0 diopters). Seven tag single-nucleotide polymorphisms (SNPs) a...

PURPOSE To evaluate myopia prevalence, myopia progression, and various potential myopia risk factors in third-year law students. DESIGN Cross-sectional study and survey. PARTICIPANTS One hundred seventy-nine third-year law students at the University of Pennsylvania. METHODS We administered a questionnaire to assess the prevalence of myopia, myopia progression, and risk factors, including ...

BACKGROUND Many efforts have been invested in slowing progression of myopia. Among the methods, atropine administration and orthokeratology (OK) are most widely used. This study analyzed the efficacy of atropine and OK lens in controlling myopia progression and elongation of axial length. METHODS This retrospective study included 105 patients (210 eyes) who wore OK lenses and 105 patients (21...

1 Associate Professor Department of Ophthalmology, Centre for Eye Research Australia, University of Melbourne, Australia Department of Ophthalmology, National University of Singapore Singapore Eye Research Institute Singapore National Eye Centre 2 Associate Professor Department of Community, Occupational and Family Medicine, National University of Singapore Department of Ophthalmology, National...