We report the production of hGM-CSF cytokine in leaves of industrial tobacco cultivars DH-17 and DH-27 by using Agrobacterium-mediated transient expression. We prove the concept that very high biomass industrial tobacco plants are suitable platforms for rapid, low cost production of foreign proteins. Successful transient expression of the GM-CSF was achieved in less than three months, opening t...

We apply the holonomic gradient method (HGM) introduced by [9] to the calculation of orthant probabilities of multivariate normal distribution. The holonomic gradient method applied to orthant probabilities is found to be a variant of Plackett’s recurrence relation ([14]). However a straightforward implementation of the method yields recurrence relations more suitable for numerical computation ...

1. Schildgen O, Müller A, Simon A. Human bocavirus and gastroenteritis [letter]. Emerg Infect Dis. 2007;13:1620. 2. Vicente D, Cilla G, Montes M, Pérez-Yarza EG, Pérez Trallero E. Human bocavirus, a respiratory and enteric virus. Emerg Infect Dis. 2007;13:636–7. 3. McIntosh K. Human bocavirus: developing evidence for pathogenicity. J Infect Dis. 2006;194:1197–9. 4. Allander T, Jartti T, Gupta S...

We apply the holonomic gradient method (HGM) introduced by [9] to the calculation of orthant probabilities of multivariate normal distribution. The holonomic gradient method applied to orthant probabilities is found to be a variant of Plackett’s recurrence relation ([14]). However an implementation of the method yields recurrence relations more suitable for numerical computation than Plackett’s...

Abstract BACKGROUNDS Recently, nuclear reactors have been replaced with accelerator-based neutron sources (ABNS) for boron capture therapy (BNCT). High-grade meningiomas (HGM) are refractory, especially recurred after some radiotherapy. We now applying randomized controlled trial (RCT) of “A phase II clinical using BNCT system refractory recurrent high-grade meningioma”. STUDY DESIGN PMDA in Ja...