نتایج جستجو برای: hey2

تعداد نتایج: 190  

2017
Sofia Perrone Lautaro Zubeldia-Brenner Elias Gazza Gianina Demarchi Leticia Baccarini Agustin Baricalla Freya Mertens Guillermina Luque Hugo Vankelecom Silvia Berner Damasia Becu-Villalobos Carolina Cristina

Pituitary adenomas are among the most frequent intracranial neoplasms and treatment depends on tumor subtype and clinical features. Unfortunately, non responder cases occur, then new molecular targets are needed. Notch system component expression and activation data are scarce in pituitary tumorigenesis, we therefore aimed to characterize Notch system in pituitary tumors of different histotype....

Journal: :Journal of cell science 2013
Xabier L Aranguren Manu Beerens Giulia Coppiello Cornelia Wiese Ine Vandersmissen Antonio Lo Nigro Catherine M Verfaillie Manfred Gessler Aernout Luttun

Endothelial cell (EC) identity is in part genetically predetermined. Transcription factor NR2F2 (also known as chicken ovalbumin upstream promoter transcription factor II, COUP-TFII) plays a key role in EC fate decision making; however, many of the underlying mechanisms remain enigmatic. In the present study, we demonstrate that NR2F2 differentially regulates gene expression of venous versus ly...

Journal: :Circulation 2011
Steffen Just Ina M Berger Benjamin Meder Johannes Backs Andreas Keller Sabine Marquart Karen Frese Eva Patzel Gerd-Jörg Rauch Hugo A Katus Wolfgang Rottbauer

BACKGROUND The molecular mechanisms that guide heart valve formation are not well understood. However, elucidation of the genetic basis of congenital heart disease is one of the prerequisites for the development of tissue-engineered heart valves. METHODS AND RESULTS We isolated here a mutation in zebrafish, bungee (bng(jh177)), which selectively perturbs valve formation in the embryonic heart...

2017
Dongyang Jiang Yuyan Lu Xiankai Li Yawei Xu Jinjiang Pang

Methods and Results-—There was a timeand dose-dependent activation of Notch1 by angiotensin II and platelet-derived growth factor in vascular smooth muscle cells. When phospholipase Cc1 (PLCc1) expression was reduced by small interfering RNA, Notch1 activation and Hey2 expression (Notch target gene) induced by angiotensin II or platelet-derived growth factor were remarkably inhibited, while Not...

Journal: :Circulation research 2007
Andreas Fischer Christian Steidl Toni U Wagner Esra Lang Peter M Jakob Peter Friedl Klaus-Peter Knobeloch Manfred Gessler

Congenital heart defects affect almost 1% of human newborns. Recently, mutations in Notch ligands and receptors have been found to cause a variety of heart defects in rodents and humans. However, the molecular effects downstream of Notch are still poorly understood. Here we report that combined inactivation of Hey1 and HeyL, two primary target genes of Notch, causes severe heart malformations, ...

2012
Olivier Boucherat Jamila Chakir Lucie Jeannotte

Hox genes encode transcription factors controlling complex developmental processes in various organs. Little is known, however, about how HOX proteins control cell fate. Herein, we demonstrate that the goblet cell metaplasia observed in lung airways from Hoxa5(-/-) mice originates from the transdifferentiation of Clara cells. Reduced CC10 expression in Hoxa5(-/-) embryos indicates that altered ...

Journal: :Blood 2012
Nicolas Ricard Delphine Ciais Sandrine Levet Mariela Subileau Christine Mallet Teresa A Zimmers Se-Jin Lee Marie Bidart Jean-Jacques Feige Sabine Bailly

ALK1 is a type I receptor of the TGF-β family that is involved in angiogenesis. Circulating BMP9 was identified as a specific ligand for ALK1 inducing vascular quiescence. In this work, we found that blocking BMP9 with a neutralizing antibody in newborn mice significantly increased retinal vascular density. Surprisingly, Bmp9-KO mice did not show any defect in retinal vascularization. However, ...

Journal: :Molecular endocrinology 2014
Dallas A Vanorny Rexxi D Prasasya Abha J Chalpe Signe M Kilen Kelly E Mayo

Ovarian follicles form through a process in which somatic pregranulosa cells encapsulate individual germ cells from germ cell syncytia. Complementary expression of the Notch ligand, Jagged1, in germ cells and the Notch receptor, Notch2, in pregranulosa cells suggests a role for Notch signaling in mediating cellular interactions during follicle assembly. Using a Notch reporter mouse, we demonstr...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Muzhou Wu Marylens Hernandez Siming Shen Jennifer K Sabo Dipti Kelkar Ju Wang Robert O'Leary Greg R Phillips Holly S Cate Patrizia Casaccia

Differentiation of oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes is regulated by the interplay between extrinsic signals and intrinsic epigenetic determinants. In this study, we analyze the effect that the extracellular ligands sonic hedgehog (Shh) and bone morphogenetic protein 4 (BMP4), have on histone acetylation and gene expression in cultured OPCs. Shh treatment favo...

2017
Tae Hoen Kim Ju-Yeon Jeong Ju-Yeon Park Se-Wha Kim Jin Hyung Heo Haeyoun Kang Gwangil Kim Hee Jung An

Tumor recurrence by obtaining chemoresistance is a major obstacle to treating ovarian cancer. By TargetScan database and a luciferase reporter assay, we identified miR-150 directly targets Notch3, which is a key oncogene in ovarian cancer. We, therefore, investigated the role of miR-150 in ovarian cancer cells, and the usefulness of miR-150 as a therapeutic target in chemoresistant ovarian canc...

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