Using a sensitive radioactive method that measures selectively the evoked release of acetylcholine, it was demonstrated that, when stimulating at 50 Hz, tubocurarine or pancuronium 2 X 10(-5) mol litre-1 or hexamethonium 10(-3) mol litre-1 significantly decreased the evoked release of acetylcholine in the mouse in vitro phrenic nerve-hemidiaphragm preparation.

IN his lecture " Medicine, Yesterday and To-morrow ", Sir Henry Dale mentioned, as the most recent addition to the technique of preparing a patient for a surgical operation, synthetic substances which, by their action on the sympathetic ganglia, lower the arterial blood pressure and enable a postural adjustment of the patient to produce a practically bloodless field of operation (Dale, 1951). I...

Our previous finding that dexamethasone-induced hypertension in rats is associated with enhanced reactivity of mesenteric arteries to arginine vasopressin but not to angiotensin II (Ang II) or norepinephrine has led us to postulate that vasopressin contributes to the development or maintenance of glucocorticoid-induced hypertension. To test this view, we investigated the effects of vasopressin,...

A proteolipid protein having a high affinity for methyl (14)C-hexamethonium, (3)H-p-(trimethylammonium)-benzene diazonium fluoroborate, and (acetyl-1-(14)C)choline chloride was isolated and purified from the electric tissue of Torpedo marmorata and Electrophorus electricus. At variance with the "receptor proteolipid" from the brain the one from electric tissue apparently does not bind atropine ...

Pancreatic exocrine secretion is affected by galanin, but the mechanisms involved are unclear. We aimed to determine the effect and elucidate the mechanism of action of exogenous galanin on basal and stimulated pancreatic amylase secretion in vitro. The effect of galanin on basal-, carbachol-, and caerulein-stimulated amylase secretion from isolated murine pancreatic lobules was measured. Carba...