Granulomatous interstitial nephritis is an uncommon but potentially reversible cause of impaired kidney function. In the native kidney, granulomatous interstitial nephritis is commonly attributed to drug hypersensitivity, sarcoidosis, or tubulointerstitial nephritis and uveitis, with a significant fraction of cases labelled as ‘idiopathic’ [1]. In kidney transplant recipients, the incidence of ...

OBJECTIVE To determine the range of various cardiac parameters using echocardiography in apparently normal, healthy English Bull Terriers. DESIGN Fourteen English Bull Terriers were selected for study. Cardiac auscultation of the parents of these dogs was normal. Echocardiographic examination of one parent of each animal showed: no mitral or aortic valve abnormalities; no myocardial lesions; ...

OBJECTIVES The British Isles Lupus Assessment Group (BILAG) index is a standardized systemic lupus erythematosus (SLE) disease activity assessment. The main aim of this study was to correlate the BILAG index with laboratory measures of disease activity in childhood-onset SLE with and without biopsy-proven lupus nephritis. METHOD Prospective observational comparison study of the BILAG index in...

INTRODUCTION Tubulointerstitial nephritis and uveitis syndrome is a disorder characterized by a combination of acute tubulointerstitial nephritis and uveitis. Immunoglobulin A nephropathy is defined by the presence of immunoglobulin A deposits in glomerular mesangial areas. In this report, we describe a rare case of tubulointerstitial nephritis and uveitis syndrome complicated by immunoglobulin...

Nearly one half of patients with lupus develop glomerulonephritis (GN), which often leads to renal failure. Although nephritis is diagnosed by the presence of proteinuria, the pathology of nephritis can fall into one of five classes defined by different forms of tissue injury, and the mechanisms involved in pathogenesis are not completely understood. Glycosphingolipids are abundant in the kidne...

objective(s)lupus nephritis (ln) is frequently associated with a poor long-term prognosis. renal biopsy is the diagnostic method of choice in this condition. urine biomarkers have been mentioned in the diagnosis of ln. the study,s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(umcp-1) as a biomarker of renal involvement in systemic lupus erythematosus.mate...

BACKGROUND Patients with lupus nephritis could progress to end-stage renal disease (10-22%); hence, kidney transplants should be considered as the treatment of choice for these patients. OBJECTIVE To evaluate the clinical outcomes after kidney transplants in patients with chronic kidney diseases secondary to lupus nephritis, polycystic kidney disease and diabetes nephropathy at Pablo Tobon Ur...

We investigated whether the C1245G polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1) gene confers the susceptibility to systemic lupus erythematosus (SLE) occurrence of lupus nephritis and affects the plasma level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in patients with SLE. A total of 45 healthy controls and 85 SLE patients were recruited. The C1245G polymorphism of the hOGG1 gene was d...

fifty-seven patients suffering from systemic lupus erythematosus with different clinical features were studied from various aspects of immunological abnormalities, including anti-nuclear antibodies; anti-dna; anti-sm (smith's antigen); and, other extractable nuclear antigens. the tests employed were microhemagglutination, counter immunoelecterphoresis, and radio immunoassay (ria). the compariso...