BACKGROUND High prevalence of herbal medicines used in pregnancy and the lack of information on their safety is a public concern. Despite this, no significant research has been done regarding potential adverse effects of using herbal medicines during pregnancy, especially among developing Asian countries. METHODS Cross-sectional studies were searched up to year 2016 on PubMed/Medline and EMBA...

This review summarizes the analytical approaches reported in the literature relating to epoxide and hydroperoxide impurities. It is intended that it should provide guidance for analysts faced by the need to control such impurities, particularly where this is due to concerns relating to their potential genotoxicity. An extensive search of the literature relating to this class of impurities revea...

Contrary to Lentz et al. (1), I suggested that the sunflower was carried from North America to Europe, not from North America to Mexico. They also misinterpret a number of early documents. In the original Mexican edition of Hernández, Ximénez (2) neither included a drawing of sunflower nor indicated its use by Indians (indios). Hernández called the sunflower chimalacatl and variants, which tran...

Antiepileptic drugs used to treat epilepsy can cause severe, life threatening side effects. In Iranian traditional medicine, herbal remedies have been used for centuries to treat seizures. In this study, the five most important herbals in Iranian traditional medicine, namely Canon, al-Hawi, al-Abniah 'an Haqaeq al Adwia, Tuhfat al-Mu'minin, and Makhzan ul-Adwia, were searched for the term "sar-...

Anxiety is a prominent indication for herbal medicine. This systematic review was therefore aimed at summarising the evidence for or against the anxiolytic efficacy of such treatments. Six databases were searched for all randomised clinical trials testing herbal monopreparations in the alleviation of anxiety. Seven such studies and one systematic review were located. Eight different herbals wer...

To the Editor: It is my opinion that meaningful co-operation between traditional healers and scientific medical practice is impossible, because of the fundamental difference in the concept of disease causation that underlies the practice of both sides. The articles in the insert to the SAMJ of December 1994 ('Bridging the gap') provided a welcome explanation of the way in which the traditional ...

Herbals and dietary supplements (HDS) can cause hepatotoxicity. Regulation of HDS varies across the globe. In the United States, it is defined by a law that is now two decades old. More recent regulatory approaches in Europe still do not require testing for premarket safety. The true incidence of hepatotoxicity from HDS is unknown. The presentation is most often with a hepatocellular enzyme pat...