In the present study we attempted to correlate the structure and function of the cry11a (72 kDa) and cry4a (135 kDa) proteins of Bacillus thuringiensis var israelensis. Homology modeling and secondary structure predictions were done to locate most probable regions for finding helices or strands in these proteins. The JPRED (JPRED consensus secondary structure prediction server) secondary struct...

a new biological active hexapeptide of c-terminal of nocistatin, contains glu-gln-lys-gln-leu-gln sequence was synthesized according to solid phase peptide synthesis on the surface of 2-chloro tritylchloride resin and using fmoc-protected amino acids in the presence of tbtu (o-(benzotriazol-1-yl)-n,n,n',n'-tetramethyl uranium tetrafluoroborate) as a coupling reagent. then, amidation o...

background: acute respiratory distress (ard) is a critical respiratory failure due to lung injury of neonates leading to the clinical appearance of poor lung compliance. the aimed of the study was to evaluate the diagnostic values in differentiating respiratory from heart diseases with using of n-terminal pro brain natriuretic peptide (nt-pro bnp) and atrial natriuretic peptide(anp) in neonates...

random peptide libraries (rpl) displayed on the surface of filamentous bacteriophages have been extensively used as a tool to map epitopes or to identify antigenic mimics (mimotpoes) of disease-specific monoclonal antibodies or polyclonal sera. these rpl are engineered by the insertion of degenerate oligonucleotides, encoding a specific number of random amino acids, in frame with a bacteriophag...

objective(s):consumption of high-fat foods is one of the major causes of obesity. physical exercise is a strategy used to counteract obesity. the aim of this study was to investigate the effect of eight weeks endurance training and high-fat diet (hfd) on appetite-regulating hormones in rat plasma. materials and methods:twenty eight male wistar rats were randomly divided into four groups: contro...

Development of peptide therapeutics generally involves screening excipients that inhibit peptide-peptide interactions, hence aggregation, and improve stability. We used the therapeutic plectasin to develop a fast method combines microscale thermophoresis titration assays molecular dynamics simulations relatively rank with respect binding affinity study key peptide-excipient interaction hotspots...

In the present study, we investigated possible involvement of TGF-β/Smad signaling pathway in osteopontin-derived SVVYGLR (SV) peptide-mediated migratory activities myogenic cells and evaluated facilitative effects SV peptide on differentiation vitro. The peptide-induced migration both human-derived satellite myoblasts was substantially suppressed by TGF-β1 receptor inhibitor SB431542 or SB5051...