نتایج جستجو برای: her2 antigen

تعداد نتایج: 214094  

2015
Alessia Lamolinara Lorenzo Stramucci Albana Hysi Manuela Iezzi Cristina Marchini Marianna Mariotti Augusto Amici Claudia Curcio

Skin represents an attractive target for DNA vaccine delivery because of its natural richness in APCs, whose targeting may potentiate the effect of vaccination. Nevertheless, intramuscular electroporation is the most common delivery method for ECTM vaccination. In this study we assessed whether intradermal administration could deliver the vaccine into different cell types and we analyzed the ev...

فاخری, تبسم, فداکار سوقه, غزل, نجفی, بهروز,

چکیده مقدمه : HER2 پروتئینی غشایی بوده و یکی از فاکتورهای تعیین کننده پیش آگهی سرطان پستان است. هدف: بررسی ارتباط پروتئین غشایی HER2با دیگر پارامترهای کلینیکوپاتولوژیک مثل اندازه، درجه آسیب شناختی تومور، وجود یا نبود تهاجم لنفی- عروقی و نیز ارتباط آن با وضعیت گیرنده های استروئیدی و P53دربیماران دچار سرطان پستان. مواد و روش‌ها: تحقیق به روش توصیفی- تحلیلی بر 465 مورد بیمار مبتلا به سرطان ...

Single chain Fragment variable (scFv) is an antibody fragment consisting variable regions of heavy and light chains. scFvs enhance their penetrability into tissues while maintaining specific affinity and having low immunogenicity. Insoluble inclusion bodies are formed when scFvs are expressed in reducing bacterial cytoplasm. One strategy for obtaining functionally active scFv is to translocate ...

2015
Banri Tsuda Yoshie Kametani Asuka Miyamoto Hirohito Miyako Nobue Kumaki Rin Ogiya Risa Oshitanai Mayako Terao Toru Morioka Naoki Niikura Takuho Okamura Yuki Saito Yasuhiro Suzuki Yutaka Tokuda

Background: Our previous predictive peptide binding studies indicated that a novel 20-mer multiple antigen peptide, CH401MAP, containing an anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibody epitope (N163-182), may potentially bind to more than 95% of class I human leukocyte antigens (HLAs) and to 30-50% of class II HLAs expressed on peripheral blood mononuclear cells (PBM...

Journal: :European journal of cancer 2014
Jetzabel García-Parra Alba Dalmases Beatriz Morancho Oriol Arpí Silvia Menendez MohammadA Sabbaghi Sandra Zazo Cristina Chamizo Juan Madoz Pilar Eroles Sonia Servitja Ignasi Tusquets Jose Yelamos Ana Lluch Joaquin Arribas Federico Rojo Ana Rovira Joan Albanell

AIM Poly (ADP-ribose) polymerase (PARP) inhibitors have shown promising results in Breast Cancer (BRCA) deficient breast cancer, but not in molecularly unselected patient populations. Two lines of research in this field are needed: the identification of novel subsets of patients that could potentially benefit from PARP inhibitors and the discovery of suitable targeted therapies for combination ...

Journal: :research in molecular medicine 0
zohreh hojati genetics division, biology department, faculty of sciences, university of isfahan, isfahan, iran zeinab hallajian genetics division, biology department, faculty of sciences, university of isfahan, isfahan, iran abolghasem esmaeili genetics division, biology department, faculty of sciences, university of isfahan, isfahan, iran majid motovali-bashi genetics division, biology department, faculty of sciences, university of isfahan, isfahan, iran hosein tabatabaeian genetics division, biology department, faculty of sciences, university of isfahan, isfahan, iran

background: amplification of her2 is seen in 20-30% of breast cancer cases. measurement of her2 gene amplification appears to be of vital importance in planning the treatment schedule for patients with breast carcinoma. the aim of our study was to evaluate her2 amplification status in malignant and benign breast tumors by differential pcr (dpcr). materials and methods: the genomic dna was extra...

Journal: :Journal of pharmaceutical research international 2021

Breast carcinoma is one of the most frequently occurring cancers among women with million cases. cancer primary cause death in around world. It major concerns public health due to its high occurrence and growing tendency. This complex functional structure develops from a highly modified apocrine sweat gland female, but remains rudimentary male. embryological into two lines along milk extending ...

ژورنال: :فصلنامه علمی- پژوهشی زیست شناسی جانوری تجربی 2012
مصطفی جمالان ابراهیم برزگری اسدآبادی

بیان غیرمعمول و عملکرد نامتعارف گیرنده فاکتورهای رشد اپیدرمی (egfrs) می‏تواند عامل ایجاد کننده بدخیمی در بافت‏های مختلف باشد. از میان تمامی اعضای خانواده egfrs، her2 گیرنده­ای می­باشد که در عدم حضور لیگاند نیز می‏تواند دیمر شده و فعال گردد. her2 دارای نقش مهمی در ایجاد سرطان پستان است. داروی هرسپتین یک آنتی­بادی مونوکلونال می­باشد که دمین خارجی her2 را هدف قرار داده و مانع از ایجاد دیمرهای فعال...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید