background and objectives: cancer is a public health problem all over the world. herbal medicines have a vital role in the prevention and treatment of cancer and large numbers of plants and their isolated constituents have shown potential anticancer activity. methods: twenty seven medicinal plants from southern iran provinces have been extracted with methanol and screened for their cytotoxic ac...

Natural herbs products (mainly herbal extract formulations) with anti-tumor effects have attracted much attention in pharmaceutical research. There are a number of herbs that have shown to have the abilities to induce apoptosis of tumor cells and play important roles in cancer prevention. Genistein, daidzein and isoflavonoids in soybean are thought to play an important role in breast cancer pre...

This work aimed to overcome the main drawbacks of some essential anticancer drugs as 5-Fluorouracil (5-FU) by controlled loading with novel drug carriers. By a differential microemulsion technique, nanosized particles derived from copolymer poly(methyl methacrylate (MMA) and 2-hydroxyethyl (HEMA)) different monomer ratios have been synthesized used carrier. Poly(MMA-co-HEMA)/MWCNT nanocomposite...

Twenty-seven naphthoquinones and their derivatives, including four new naphthalenyl glucosides and twenty-three known compounds, were isolated from green walnut husks, which came from Juglans mandshurica Maxim. The structures of four new naphthalenyl glucosides were elucidated based on extensive spectroscopic analyses. All of these compounds were evaluated for their cytotoxic activities against...

Antioxidant activities of wampee peel extracts using five different solvents (ethanol, hexane, ethyl acetate, butanol and water) were determined by using in-vitro antioxidant models including total antioxidant capability, 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, reducing power, and superoxide scavenging activity. Ethyl acetate fraction (EAF) exhibited the highest antio...

A liquid chromatography-diode array detection-electrospray ionization mass spectrometric (HPLC– PDA–ESI/MS/MS) method was used for separation and characterization of the phytoconstituents of the aqueous acetone leaf extract of Eucalyptus camaldulensis Dehnh (Myrtaceae). The employed method was optimized for separation, identification and quantification of fifty six compounds including ellagitan...

Phytoecdysteroids from aerial parts of Silene guntensis B. Fedtsch were investigated and three phytoecdysteroids were isolated: 2,3-diacetate-22-benzoate-20-hydroxyecdysone (1), 2-deoxy-20-hydroxyecdysone (2), and 20-hydroxyecdysone (3). Their chemical structures were elucidated by DEPT, COSY, 1H and 13C NMR spectroscopy. The isolated compounds 1-3 and crude extracts were evaluated for their an...

Five new shionane-type triterpenes, astataricusones A-D (compounds 1-4) and astataricusol A (5), together with one known shionane-type triterpene 6 were obtained from the roots and rhizomes of Aster tataricus L. f. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configurations of 1 and 4 was determined by single crystal X-ray diffraction...

Purpose: To investigate the molecular mechanisms underlying the role of Ixeris dentataa extract (IDE) in the prevention of high glucose-induced lipid accumulation in human HepG-2 hepatocytes. Methods: IDE extract was prepared by maceration in ethyl acetate. Its fractionation was carried out by column chromatography. HepG-2 cells were pretreated with various concentration of IDE (0, 10, 20, 40 a...