Decreased expression of the tCR ζ-chain has been reported in several autoimmune and inflammatory diseases. Recent evidence suggests that this deficiency may be due to polymorphisms in the CD247 gene. A total 52 patients with systemic lupus erythematosus (Sle) and 95 healthy controls of Bulgarian ethnicity were genotyped for 837C>g, rs1052230, 844A>t, and rs1052231 using a taqMan genotyping assa...