نتایج جستجو برای: hematologic stem cell transplantation
تعداد نتایج: 1903173 فیلتر نتایج به سال:
conclusions apbsc transplantation greatly benefits hbv-linked decompensated cirrhosis patients and should be recommended in clinical practice. patients and methods this prospective study included 68 hospitalized patients who were diagnosed with hbv-related decompensated cirrhosis. these patients were divided into two groups: the transplantation group included 33 patients, while the control grou...
primary immunodeficiencies constitute a group of highly complex congenital disorders most of which are characterized by a very poor prognosis. allogeneic hematopoietic stem cell transplantation (hsct) has become an established curative treatment approach in many of these disorders, which may be permanently corrected. in this presentation basic and practical aspects of hsct are presented, with a...
introduction: the traditional goal of the treatment of acute myelogenous leukemia is to produce and maintain a complete remission (cr).the difference in survival time was entirely attributable to the duration of time spent in cr .in this study, the outcome of aml patients with allogeneic hsct in cr1 versus other than cr1 was compared. patients and methods: since march 1991 until november 2008, ...
objective: to evaluate the potential advantages of imipenem/cilastatin in control of fever in neutro-penic hsct recipients.patients and method: in this single-center study, 111 consecutive febrile episodes in 104 neutropenic hsct recipients with a mean age of 26 years were randomized to treatment either with imipenem/cilastatin 1 g, iv, q8h or cefepime (our standard regimen) 2 g, iv, q8h. if fe...
Background and Objective: Cell therapy is one of the attractive and novel approaches in the treatment of chronic wounds. The aim of this study was to evaluate the function of bone marrow derived hematopoietic stem cells (CD93) in the treatment of diabetic ulcers. Materials and Methods: In this study, 15 BALB/c strain mice, weighing 25-30 g were used, of which 10 were made diabetic by s...
Patients with hematologic malignancies were conditioned using a rabbit antithymocyte globulin-based reduced-intensity conditioning regimen for allogeneic stem cell transplantation. Donor-derived CD3(+) cell count (ddCD3), a product of CD3(+) cell chimerism and absolute CD3(+) cell count, when <110/μL at 8 weeks post-stem cell transplantation predicted a high risk of sustained mixed chimerism an...
stem cell-based therapies have recently opened up new horizons for treatment of various types of diseases including diabetes mellitus. however, long-term efficacy and safety of these novel modalities still remain a serious question. hereby, we aim to report the one-year follow-up results in the diabetic patients who underwent fetal liver-derived hematopoietic stem cell allotransplantation. fift...
Pluripotent stem cells (PSCs) may be offered as an unlimited cell source for the hepatocyte generation. The generation of hepatocytes from stem cells in vitro would provide an alternative cell source for applications in drug discovery and cell transplantation. In this review, we discuss different approaches to generate pluripotent stem cell-derived hepatocytes, advantages, limitations for each ...
Allogeneic hematopoietic stem cell transplantation is increasingly used as treatment for patients with life-threatening blood diseases. Its curative potential is largely based on immune-mediated graft-versus-leukemia effects caused by donor T cells contained in the graft. Unfortunately, donor T cells are also the cause of graft-versus-host disease. The vast majority of human leukocyte antigen-m...
Multiple myeloma (MM) is one of the key hematologic malignancies in which the impact of dose intensity has been demonstrated. Consequently, in 2005, MM was the most common disease for which autologous stem cell transplantation (ASCT) was indicated both in Europe and in the U.S. However, ASCT is not curative, and most patients relapse within a median of 3 years. Novel agents such as thalidomide ...
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