نتایج جستجو برای: hematologic disease
تعداد نتایج: 1502143 فیلتر نتایج به سال:
The treatment of subacute combined degeneration of the spinal cord (SCDSC) is based on a pretended etiological unity between the hematologic and neurologic manifestations, according to the old concept of the neuro-anemic syndrome. The first attempt of treatment of that disease was the liver therapy, introduced in 1926 by Minot and Murphy 2 3 , but the neurologic results did not correspond to th...
PURPOSE Irinotecan (CPT-11) is approved in metastatic colorectal cancer treatment and can cause severe toxicity. The main purpose of our study was to assess the role of different polymorphisms on the occurrence of hematologic toxicities and disease-free survival in high-risk stage III colon cancer patients receiving 5-fluorouracil (5FU) and CPT-11 adjuvant chemotherapy regimen in a prospective ...
Objective To evaluate the threshold for platelet transfusion in children admitted to a pediatric intensive care unit (PICU). This is a retrospective chart review study, conducted at our tertiary level PICU and is related to critically ill pediatric patients who required platelet transfusion. Methods We retrieved the target patient population data from our blood bank database. The patients were ...
Hematologic malignancy is a risk factor for severe coronavirus disease 2019 (COVID-19) in adults; however, data specific to children with leukemia are limited. High-quality infectious adverse event from the ongoing Children's Oncology Group (COG) standard-risk B acute lymphoblastic leukemia/lymphoma (ALL/LLy) trial, AALL1731, were analyzed provide disease-specific estimate of SARS-CoV-2 infecti...
Multiple myeloma (MM) is a hematologic cancer characterized by clonal proliferation of plasma cells in the bone marrow (BM). The progression, from early stages disease as monoclonal gammopathy undetermined significance (MGUS) and smoldering multiple (SMM) to MM occasionally extramedullary disease, drastically affected tumor microenvironment (TME). Soluble factors direct cell–cell interactions r...
Korean National Health Insurance (NHI) was introduced in 1963 and became a nationwide health insurance after several law reforms in 1988. As a result of nationalization, coverage has expanded, and its service level has greatly improved since 1998 [1]. However, several diagnostic and therapeutic modalities for rare, incurable diseases such as malignant hematologic diseases are excluded from the ...
Kasabach-Merritt phenomenon (KMP) is relatively rare in childhood and adolescents with high mortality rate because of its hemorrhagic complications and unresponsiveness to treatments such as corticosteroids, vincristine, intravascular embolization, and/or surgery. Propranolol, a β -adrenergic receptor blocker, has a promising efficacy against vascular tumors such as infantile hemangiomas. But l...
Of 11 children with juvenile myelomonocytic leukemia (JMML) carrying RAS mutations (8 with NRAS mutations, 3 with KRAS2 mutations), 5 had a profound elevation in either or both the white blood cells and spleen size at diagnosis. Three patients had no or modest hepatosplenomegaly and mild leukocytosis at presentation but subsequently showed a marked increase in spleen size with or without hemato...
ASH represents more than 15,000 hematologists who are committed to the treatment of blood and blood-related diseases. These diseases include anemias (such as sickle cell disease and thalassemia), thrombosis and bleeding disorders, as well as malignant hematologic disorders such as leukemia, lymphoma, and myeloma. ASH members include clinicians who order Next Generation Sequencing (NGS) diagnost...
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