نتایج جستجو برای: hela kb mda mb 468

تعداد نتایج: 84493  

2016
Meghna Mehta Kanthesh Basalingappa James N. Griffith Daniel Andrade Anish Babu Narsireddy Amreddy Ranganayaki Muralidharan Myriam Gorospe Terence Herman Wei-Qun Ding Rajagopal Ramesh Anupama Munshi

HuR is an mRNA-binding protein whose overexpression in cancer cells has been associated with poor prognosis and resistance to therapy. While reports on HuR overexpression contributing to chemoresistance exist, limited information is available on HuR and radioresistance especially in triple-negative breast cancer (TNBC).In this study we investigated the role of HuR in radiation resistance in thr...

2017
He JingSong Guan Hong Jianbo Yang Zheng Duo Fu Li Chen WeiCai Luo XueYing Mao YouSheng OuYang YiWen Pan Yue Chang Zou

Triple-negative breast cancer (TNBC) is more aggressive than other breast cancer subtypes. Collagen type IV alpha 2 (COL4A2), a major component of the basement membrane, dynamically influences a wide range of biological processes, including cancer pathogenesis and progression. This study evaluated the effects of COL4A2 siRNA delivered by lentiviral vector to TNBC cells. COL4A2 siRNA lenti-viral...

2017
Song Park Yonghun Sung Jain Jeong Minjee Choi Jinhee Lee Wookbong Kwon Soyoung Jang Si Jun Park Hyeng-Soo Kim Mee-Hyun Lee Dong Joon Kim Kangdong Liu Sung-Hyun Kim Zigang Dong Zae Young Ryoo Myoung Ok Kim

Breast cancer is the most abundant cancer worldwide and a severe problem for women. Notably, breast cancer has a high mortality rate, mainly because of tumor progression and metastasis. Triple-negative breast cancer (TNBC) is highly progressive and lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Therefore, there ar...

2011
Mahavir B. Chougule Apurva R. Patel Tanise Jackson Mandip Singh

BACKGROUND The aim of this study was to investigate the anticancer activity and mechanism of action of Noscapine alone and in combination with Doxorubicin against triple negative breast cancer (TNBC). METHODS TNBC cells were pretreated with Noscapine or Doxorubicin or combination and combination index values were calculated using isobolographic method. Apoptosis was assessed by TUNEL staining...

Journal: :iranian journal of toxicology 0
حجت صادقی علی آبادی hojjat sadeghi-aliabadi school of pharmacy and pharmaceutical sciences, isfahan, iran. حسین موسوی hossein mosavi isfahan university of medical sciences, isfahan, iran. مینا میریان mina mirian isfahan university of medical sciences, isfahan, iran. سعید کاخکی saeed kakhki shahid beheshti university of medical sciences, tehran, iran. افشین زرقی afshin zarghi shahid beheshti university of medical sciences, tehran, iran.

background: flavonoids have a variety of biological activities, such as anti-allergic, anti-inflammatory, anti-oxidative, free radical scavenging, and anti-mutagenic. methods: the cytotoxic effects of three synthesized flavonoid derivatives (k3, k4 and k5) were evaluated against hela , mda-mb -231 and ht-29 cancer cells using mtt assay. results: the results showed that these flavonoids were not...

Journal: :research in molecular medicine 0
abasalt hosseinzadeh colagar omolbanin amjadi reza valadan alireza rafiei

background: understanding of cellular and molecular mechanisms involved in cell/tumor growth and progression has led to molecular-targeted therapy. her1 and her2 are two main oncogenic components of her-receptor family considered as targets for cancer research and therapy. reliable results of her- related research and targeted therapies dependent upon cell line with known her expression status....

Hosseinkhani, Saman, Khamehchian, Sedigheh, Nikkhah, Maryam,

Background: Cell penetrating peptides (CPPs) can enter a cell through the cell membrane, and used in the fields of drug delivery, gene therapy, and cancer therapy by their property transporting various molecules into cytoplasm. Gold nanospheres (GNSs) are a useful tool for molecular imaging, because they are not cytotoxic and have high solubility, excellent light scattering property and ease of...

Mina Mirian , Afshin Zarghi , Hojjat Sadeghi-Aliabadi , Hossein Mosavi, Saeed Kakhki ,

Background: Flavonoids have a variety of biological activities, such as anti-allergic, anti-inflammatory, anti-oxidative, free radical scavenging, and anti-mutagenic. Methods: The cytotoxic effects of three synthesized flavonoid derivatives (K3, K4 and K5) were evaluated against Hela , MDA-MB -231 and HT-29 cancer cells using MTT assay. Results: The results showed that these flavonoids were n...

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