N-Substituted amides and lactams are rapidly N-alkylated under solvent-free phase-transfer catalytic conditions using microwaves.

In the present investigation, a series of 4-(4-(dimethylamino) benzyl)-3-methyl-1Hpyrazol-5(4H)-one analogues of pyrazole were synthesized by cyclization of mannich base with hydrazine hydrate. The nitrogen functionality of 4-(4-(dimethylamino) benzyl)-3-methyl-1Hpyrazol-5(4H)-one was alkylated with different halogenated alkylated substituted chain in the presence of base. The chemical structur...

Benzonitrile (c-C6H5CN, where ‘c’ indicates a cyclic structure), polar proxy for benzene (c-C6H6), has the potential to serve as highly convenient radio probe aromatic chemistry, provided that this ring can be found in other astronomical sources beyond molecule-rich prestellar cloud TMC-1. Here we present evidence of benzonitrile four prestellar, and possibly protostellar, sources: Serpens 1A, ...

The Escherichia coli AlkB protein is a 2-oxoglutarate/Fe(II)-dependent demethylase that repairs alkylated single stranded and double stranded DNA. Immunoaffinity chromatography coupled with mass spectrometry identified RecA, a key factor in homologous recombination, as an AlkB-associated protein. The interaction between AlkB and RecA was validated by yeast two-hybrid assay; size-exclusion chrom...

Benzene, Toluene, Ethyl Benzene and Xylene are volatile organic compounds (VOCs) with approximately similar physical and chemical characteristics. Benzene and Ethyl-benzene are known carcinogen as well as they affect the circulatory, nervous, and reproductive and respiratory systems. Toluene and Xylene also damage the nervous and reproductive systems. The main purpose of this study is to determ...