The molecular chaperone, heat shock protein 70 (Hsp70), acts at multiple steps in a protein's life cycle, including during the processes of folding, trafficking, remodeling and degradation. To accomplish these various tasks, the activity of Hsp70 is shaped by a host of co-chaperones, which bind to the core chaperone and influence its functions. Genetic studies have strongly linked Hsp70 and its...

background: taenia multiceps is a cestode parasite with its larval stage(metacestode), coenurus cerebralis , mainly encysts in the central nervous system of sheep and other livestock causing cerebralis coenurosis. since treatment of coenurosis with chemotherapy showed little effect and surgical removal of cysts is not advisable in field conditions, vaccination is useful to control coenurosis. p...

CaHSP70 (70 kDa heat shock protein) is a highly immunogenic protein of Candida albicans. We have studied heat shock-induced expression of the CaHSP70 gene under germ tube-inductive and non-inductive conditions. The CaHSP70 upstream regulatory region was cloned and sequenced. It contains at least three heat shock elements (HSEs), specific DNA sequences that are bound by the heat shock transcript...

objective(s):hyperglycemia worsens the neuronal death induced by cerebral ischemia. previous studies demonstrated that diabetic hyperglycemia suppressed the expression of heat shock protein 70 and 60 (hsp70 and 60) in the liver. igg antibody titres against heat shock protein 27 (anti hsp27) were measured to determine whether hyperglycemia exacerbates ischemic brain damage by suppressing the exp...

We present a detailed comparison of two self-consistent equation-ofstate models which differ from their electronic contribution: the atom in a spherical cell and the atom in a jellium of charges. It is shown that both models are well suited for the calculation of Hugoniot shock adiabats in the high pressure range (1 Mbar-10 Gbar), and that the atom-in-a-jellium model provides a better treatment...

OBJECTIVE Since insulin stimulates nitric oxide (NO) production and an increase in NO following heat shock is required for myocardial heat shock protein 70 (Hsp70) synthesis, we hypothesized that insulin would enhance myocardial Hsp70 synthesis by augmenting NO signaling. We examined whether a physiologic dose of insulin increased myocardial Hsp70 in unstressed and heat shock treated rats. ME...