boembolic events, seven were TIAs without major sequelae, two patients had permanent deficit and one patient died. Eighty-eight patients remained on long-term anticoagula-tion because of AF. There were six reported haemorrhagic complications, for an actuarial rate of 95.6"1.97% patients free of anticoagulation related haemorrhage at 15 years for the total series and 91% for the 88 patients rece...

Introduction:  In patients who underwent surgery to repair Tetralogy of Fallot, right ventricular dilation from pulmonary regurgitation may be result in right ventricular failure, arrhythmias and cardiac arrest. Hence, pulmonary valve replacement may be necessary to reduce right ventricular volume overload. The aim of present study was to assess the effects of pulmonary valve replacement on rig...

OBJECTIVES The present study evaluates the long-term course of aortic valve disease and the need for aortic valve surgery in patients with rheumatic mitral valve disease who underwent mitral valve surgery. BACKGROUND Little is known about the natural history of aortic valve disease in patients undergoing mitral valve surgery for rheumatic mitral valve disease. In addition there is no firm pol...

Background: Mitral valve disease is the most common acquired heart disease in dogs. Mitral valve regurgitation (MR) due to endocardiosis is an important cause of morbidity and mortality in dog. Echocardiography as a non-invasive tool is routinely used to evaluate and diagnose different disorders in the heart. Objectives: The purpose of this study is to determine the efficacy of medical treatmen...

Although there is very little high quality evidence to guide the medical treatment of valve disease, this is an important area of cardiology for two reasons. Firstly, there are many frail older people with symptomatic degenerative valve disease in whom the risks of surgical intervention are prohibitive and medical treatment is the only realistic option. Secondly, there is a real and exciting pr...

RATIONALE Elastin is a ubiquitous extracellular matrix protein that is highly organized in heart valves and arteries. Because elastic fiber abnormalities are a central feature of degenerative valve disease, we hypothesized that elastin-insufficient mice would manifest viable heart valve disease. OBJECTIVE To analyze valve structure and function in elastin-insufficient mice (Eln(+/-)) at neona...

OBJECTIVE Heart valve abnormalities are commonly found in patients with antiphospholipid syndrome but experience with valve replacement in such patients is limited. We analyzed the results of valve replacement in patients with this condition at our institution. METHODS Between 1989 and 2002, 10 patients with antiphospholipid syndrome (8 women, 2 men; aged 38-73 years, mean 49 years) with seve...

introduction: infective endocarditis (ie) causes serious complications in patients. congenital heart disease (chd) is an important underlying condition in children. case presentation: a 6-year-old girl with ventricular septal defect (vsd) was presented. echocardiography revealed large vegetation in right ventricular outflow tract near the pulmonary valve. the patient showed clinical symptoms of...

Valvular heart disease presents as mixed spectrum lesion in healthcare settings in the third-world and developing countries. Rheumatic heart disease still forms the bulk of the aetiopathology of valve lesions. Mitral and aortic valve lesions top the list of valvular pathology. A thorough understanding of the pathophysiology of valvular heart disease is essential while planning anaesthesia and p...

Partial muscular inter-ventricular septal defect (VSD) or Pacman heart is a rare congenital or occasionally acquired anomaly. Concurrent Pacman heart and Shone's complex are extremely rare and have never been reported until now. We described a 37-year-old male patient with congenital Pacman heart, flail mitral valve (FMV), and a history of multiple congenital anomalies, including subvalvular ao...