Transthoracic and transoesophageal cardiac echocardiography and Doppler investigations were performed in 31 consecutive patients with malignant midgut carcinoid tumours. The transoesophageal images allowed measurement of the thickness of the atrioventricular valve leaflets and the superficial wall layers on the cavity side of both atria. The mean thickness of the anterior tricuspid leaflet was ...

Diarrhoea and skin flushing are characteristic features of the carcinoid syndrome. The diarrhoea is thought to be caused mainly by 5-hydroxytryptamine (5-HT) (Grahame-Smith, 1972) whereas the possible causes of the flushing attacks include bradykinin (Oates et al., 1964), prostaglandins (Sandler, Karim and Williams, 1968; Kaplan et al., 1973) 5-HT (Page and McCubbin, 1953) and noradrenaline and...

Objective: Primary ovarian carcinoids are neuroendocrine tumors, representing up to 1% of all tumors. In this paper, the authors aimed at analyzing clinical and pathological aspects recently published carcinoid, providing new correlations regarding them. Mechanism: The have reviewed cases primary carcinoid reported in international journals since 2005 date. A total 99 68 articles been found ana...

BACKGROUND AND OBJECTIVES Surgery in carcinoid patients can provoke a carcinoid crisis, which can have serious sequelae, including death. Octreotide prophylaxis is recommended to prevent carcinoid crisis, however there are few reports of outcomes and no large series examining its efficacy. We hypothesized that a 500 µg prophylactic octreotide dose is sufficient to prevent carcinoid crisis. ME...

Carcinoids are neuroendocrine tumours which may secrete hormones like gastrin, insulin, ACTH, etc. Liver is a common site for metastasis of carcinoid origin and an unusual site for a primary carcinoid tumour to arise.We present the case of a 51-year-old Caucasian man with diarrhoea, weight loss, duodenum ulcers and a liver mass in ultrasonography. A primary hepatic carcinoid tumour with a Zolli...

A carcinoid crisis is a severe complication of the carcinoid syndrome that can arise in patients with advanced metastatic neuroendocrine tumors. It can be initiated by stress, catecholamines, and tumor manipulation. In this article, we report a case in which an injection with the catecholamine tracer 6-18F-fluorodihydroxyphenylalanine, used for PET, induced a carcinoid crisis. Octreotide can be...

RATIONALE Typical pulmonary carcinoid is a kind of low-grade malignancy neuroendocrine tumor. Cushing's syndrome is a very rare clinical feature of typical pulmonary carcinoid caused by hypercorticism. Complete tumor resection is the standard curative treatment for primary typical pulmonary carcinoid. However, our knowledge on the gene level of typical pulmonary carcinoid is limited. PATIENT ...

Excessive serotonin secretion is the hallmark of carcinoid syndrome. It leads to diarrhea, cramping, abdominal pain, wheezing and flushing. It is also associated with serious cardiac valve disease and lower life expectancy. Efforts to control serotonin production in carcinoid syndrome are currently limited to the use of somatostatin analogues and antitumor therapies such as surgery, radiation, ...