BACKGROUND The purpose of this study was to determine prospectively both human papillomavirus (HPV) load and physical status in different types of head and neck squamous cell carcinoma (HNSCC). METHODS HPV DNA, E6/E7 mRNA expression, viral load, and physical status of 184 patients with HNSCC were examined simultaneously by polymerase chain reaction (PCR)-based methods. RESULTS The HPV genom...

OBJECTIVES/HYPOTHESIS To describe the management and outcomes of Fanconi anemia (FA) patients with head and neck squamous cell carcinoma. STUDY DESIGN Cohort study. METHODS Demographic information, prognostic factors, therapeutic management, and survival outcomes for FA patients enrolled in the International Fanconi Anemia Registry who developed head and neck squamous cell carcinoma (HNSCC)...

Background: Head and neck squamous cell carcinoma (HNSCC) is a devastating disease that has generally poor prognosis. Cisplatin-based therapies remain the standard of care for these patients, however, many patients experience acute toxic effects develop resistance to treatment. Polyamine metabolism been shown promote growth cancer cells. AMXT-1501 compound in clinical trials inhibits polyamine ...

The mechanism of hypoxanthine-guanine phosphoribosyltransferase 1 (HPRT1) upregulation and its function in head neck squamous cell carcinoma (HNSCC) remains obscure. Herein, the expression HPRT1 underlying HNSCC were explored. Firstly, prognostic values simultaneously validated using bioinformatic analysis quantitative real-time PCR (qRT-PCR), immunohistochemistry staining with local samples. e...

Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers in world, with surgery, radiotherapy, chemotherapy, immunotherapy being primary treatment modalities. The for HNSCC has evolved over time, due to which prognosis improved drastically. Despite varied options, major challenges persist. chemotherapeutic immunotherapeutic drugs are usually administered systemically, cou...

Elevated levels of prostaglandin E(2) (PGE(2)) occur in head and neck squamous cell carcinoma (HNSCC) and have been associated with a poor prognosis. Recently, an inducible microsomal prostaglandin E synthase-1 (mPGES) was identified. This enzyme converts the cyclooxygenase product prostaglandin H(2) (PGH(2)) to PGE(2). Given the apparent significance of PGE(2) in carcinogenesis, it is importan...

Glucocorticoids (GC) are widely used to counter the adverse events during cancer therapy; nonetheless, previous studies pointed out that GC may reduce efficacy of chemotherapy on cells, especially in epidermal growth factor receptor (EGFR)-targeted therapy head and neck squamous cell carcinoma (HNSCC) remaining be elucidated. The primary aim present study was probe into GC-induced resistance EG...

the association of squamous cell carcinoma of the larynx with thyroid papillary carcinoma is an unusual finding. from 2004 to 2011, approximately 250 patients underwent laryngectomies due to squamous cell carcinoma of the larynx at the otolaryngology department of khalili hospital, affiliated with shiraz university of medical sciences, shiraz, iran. in three patients, synchronous occurrence of ...

Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is considered to be a distinct clinical entity with better prognosis than the classical tobacco- and alcohol-associated tumors. The increasing incidence of this neoplasia during the last decades highlights the need to better understand the role of HPV in the development of these cancers. Although the proportion of ...