Elevated levels of endogenous tissue-type plasminogen activator (t-PA) appear to be a marker for preclinical atherosclerosis. At present, however, data describing potential relations between plasma t-PA level and established lipid risk factors for coronary atherosclerosis are sparse. To explore these potential relations, we measured plasma levels of t-PA antigen (t-PA:ag) in 633 apparently heal...

In the present work we investigated HDL-C and its subfractions HDL2 and HDL3 as well as total cholesterol (TC), triglycerides (TG), LDL-C, VLDL-C, apolipoproteins A1 (ApoA1) and B (ApoB) and lipoprotein (a) (Lp(a) in 25 patients with newly diagnosed acute lymphocytic leukemia (ALL) before and after induction treatment. The mean basal plasma levels of TC, HDL-C and its subfractions, LDL-C, and A...

The effect on serum high density lipoprotein subfractions of a low fat diet with a high ratio of polyunsaturated-to-saturated fatty acids was studied in 38 middle-aged volunteers (19 men and 19 women) in North Karelia, Finland. The mean serum HDL2 cholesterol decreased from 32 +/- 2 mg/dl (mean +/- SE) to 28 +/- 2 mg/dl (p less than 0.001) during the experimental diet and returned to 33 +/- 2 m...

High-density lipoprotein (HDL) levels were studied in 10 male patients with severe coronary atherosclerosis and in 10 well-matched controls. All subjects were normolipidemic, and the presence of a disease or other factor influencing HDL levels were excluded. Very low density lipoprotein and low-density lipoprotein levels were similar in both groups, but HDL concentration was significantly lower...

OBJECTIVES To show that lipid and lipoprotein levels and cell sodium and potassium content and transport could change depending on the degree of hypertension. DESIGN AND METHODS Forty-three hypertensive patients and 20 healthy subjects were recruited at the Cardiology and Biochemistry Departments of Tlemcen University Hospital Centre (Northwest of Algeria). RESULTS Levels of CHOL, TG, PL, H...

The difference in HDL-lipid constituents was examined in sera from the hepatic vein and femoral artery. In HDL, HDL2 and HDL3 the most pronounced difference existed in the triglyceride concentration which was significantly higher in the femoral artery as compared to the hepatic vein. The cholesterol and phospholipid concentrations of HDL2 alone but not of HDL3 were also significantly higher in ...

Epidemiological studies have shown that HDL-C is negatively correlated with coronary arteriosclerosis . This is because HDL transports cholesterol from peripheral tissues to the liver, playing a major role in the system for reverse transport of cholesterol (RCT), and having an anti-arteriosclerosis action. The particle size, lipid content, and apolipoprotein components of HDL is heterogeneous. ...

Carotid Lipid Core Measured by MRI To the Editor: A strong relationship exists between cholesterol and atherosclerosis,1 with low density lipoprotein (LDL) being a major risk factor.2 However, 50% of patients with acute coronary events have “normal” cholesterol, and 75% patients with premature coronary heart disease (CHD) have normal LDL.3 Thus, contribution of other lipoproteins has been explo...