The holy grail of anticancer therapy is to selectively eradicate malignant cells while sparing their normal counterparts. Tremendous progresses have been made in this sense during the past decade, as demonstrated by the development and subsequent integration into the clinical routine of ever more effective and safe therapeutic agents. Among these, chemical inhibitors of oncogenic drivers such a...

Immersive virtual environment (IVE) systems allow users to control their virtual viewpoint by moving their tracked head and by walking through the real world, but usually the virtual space which can be explored by walking is restricted to the size of the tracked space of the laboratory. However, as the user approaches an edge of the tracked walking area, reorientation techniques can be applied ...

a Information, Evidence and Research Cluster; Member of the WHO Ethics Review Committee. World Health Organization, 20 avenue Appia, 1211 Geneva 27, Switzerland. Correspondence to Michel Thieren (e-mail: [email protected]). b Institut d’éthique biomédicale, Centre médical universitaire, Université de Genève, Switzerland. doi: 10.2471/BLT.07.045443 This month marks sixty years since the Nuremberg...

Beta-Hairpins with short connecting loops (1-5 residues) have been identified from a data set of 250 non-homologous, high resolution (< or =2.0 A) protein crystal structures. The conformational preferences of the loop segments have been analyzed with the specific aim of identifying frequently occurring motifs. Type I' and II' beta-turns were found to have a high propensity for occurrence in two...