“IS THERE A DIFFERENCE BETWEEN KNOWLEDGE AND information?” is the question that participants in this symposium were asked to address. I come to the question as an historian of economic thought who has studied the Austrian tradition, and in particular the contributions of F.A. Hayek, who is remembered among information theorists for his early writings on “the knowledge problem.” An analysis of h...

In the high-choice media landscape, satire has potential to help news and politics break through information apathy barriers reinvigorate democratic debate. While scholarly attention genre of increased, interest in satirists themselves been sparse. Using a theory non-deliberative forms public discourse idea role conceptions, this study presents an analysis interviews with Swedish working broadc...

We study the properties of various Eulerian contributions to fluid particle acceleration by using well-resolved direct numerical simulations isotropic turbulence, with grid resolution as high $12288^3$ and Taylor-scale Reynolds number $R_\lambda$ in range between 140 1300. The variance convective acceleration, when normalized Kolmogorov scales, increases linearly $R_\lambda$, consistent simple ...

Tamoxifen, an antiestrogen used in the prevention and treatment of breast cancer, is extensively metabolized by cytochrome P450 enzymes. Its biotransformation to α-hydroxytamoxifen (α-OHT), which may be genotoxic, and to N-desmethyltamoxifen (N-DMT), which is partially hydroxylated to 4-hydroxy-N-DMT (endoxifen), a potent antiestrogen, is mediated by CYP3A enzymes. However, the potential contri...

Targeting death receptors with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has the remarkable potential to selectively kill malignant cells whereas normal cells are largely unaffected by this treatment. However, some tumor cells, including leukemia cells, exhibit resistance to this molecule. To investigate the basis for resistance of leukemia cells to the zinc-bound form of ...

The inference of fault geometry from suprajacent fold shape relies on consistent and verified forward models of fault-cored folds, e.g. suites of models with differing fault boundary conditions demonstrate the range of possible folding. Results of kinematic (fault-parallel flow) and mechanical (boundary element method) models are compared to ascertain differences in the way the two methods simu...

TCR V genes show differing expression patterns, termed skewing, in CD4+ and CD8+ subsets of T lymphocytes. To determine which elements of the TCR V regions contribute to these observed TCR V gene skewing patterns, we have performed an in-depth analysis, taking advantage of RT-PCR and DNA sequencing, which was focused on the multi-member TCRBV6 gene family. These studies allowed us to evaluate t...

We have shown previously that fibrin(ogen) binds fibroblast growth factor 2 (FGF-2) and potentiates stimulation of endothelial-cell (EC) proliferation. We have now used 2 FGF-2 mutants differing only in the 5 residues constituting the binding site to characterize the importance of this interaction in angiogenesis. The nonbinding (2212) and binding (221*2) mutants stimulated EC proliferation by ...

We present a collision attack on the hash function HAS-160 reduced to 53-steps. The attack has a complexity of about 2 hash computations. The attack is based on the work of Cho et al. presented at ICISC 2006. In this article, we improve their attack complexity by a factor of about 2 using a slightly different strategy for message modification in the first 20 steps of the hash function.