Actinomycin D (AD) produces in most cultured cell lines a complete and essentially irreversible inhibition of DNA-dependent RNA synthesis (Reich et al ., 1961 ; Girard et al ., 1964) . Several RNA species are reported to be AD resistant (Paul and Struthers, 1963 ; Roberts and Newman, 1966 ; Penman et al ., 1968 ; Perry et al ., 1970; Dubin and Montenecourt, 1970) . On the cellular level, a numb...

Dr K COWCHER, Mr E McELLIGOTT, and Dr G W HANKS (Royal Marsden Hospital, Sutton, Surrey SM2 5PT) write: Recent experience with a patient with advanced cancer and insulin dependent diabetes has brought to our attention the sugar content of Oramorph, a recently introduced formulation of oral morphine sulphate solution. Oramorph is manufactured in two strengths, 10 mg in 5 ml and 100 mg in 5 ml, a...

STUDY OBJECTIVE To determine if inhalation of grain sorghum dust in the laboratory would cause neutrophilic upper and lower respiratory tract inflammation in human volunteers, as well as systemic signs of illness. DESIGN Prospective. SETTING University of Nebraska Medical Center. PARTICIPANTS Thirty normal volunteers. INTERVENTIONS Inhalation challenge with 20 mL of a nebulized solution...

Endovascular stents made of the superelastic nickel-titanium alloy Nitinol are subjected in service to tens of millions of loading cycles and even "single-event" overloads, both of which can potentially result in fracture and/or complete failure of the device. A fracture-mechanics-based methodology can provide a means to quantify relevant material parameters critical to the design against such ...

The propagation of mammalian cells in stainless steel fermentors of a type used in antibiotic fermentations represents a marked departure from the techniques employed in classical tissue culture studies. Since the pioneer work of Harrison (1907), in which he demonstrated the outgrowth of cells from nerve tissue maintained in vitro, many techniques for the in vitro culture of cells have been dev...

The propagation of mammalian cells in stainless steel fermentors of a type used in antibiotic fermentations represents a marked departure from the techniques employed in classical tissue culture studies. Since the pioneer work of Harrison (1907), in which he demonstrated the outgrowth of cells from nerve tissue maintained in vitro, many techniques for the in vitro culture of cells have been dev...

We demonstrate here a method for the verified solution of nonlinear ODE models in physiology, computing rigorous bounds on the trajectories of the state variables, based on the ranges of the uncertain parameters. We also demonstrate an approach for the propagation of uncertain probability distributions in one or more model parameters and/or initial conditions. Assuming an uncertain probability ...