نتایج جستجو برای: hamster
تعداد نتایج: 16455 فیلتر نتایج به سال:
Chinese hamster ovary (CHO) cells, first isolated in 1957, are the preferred production host for many therapeutic proteins. Although genetic heterogeneity among CHO cell lines has been well documented, a systematic, nucleotide-resolution characterization of their genotypic differences has been stymied by the lack of a unifying genomic resource for CHO cells. Here we report a 2.4-Gb draft genome...
MicroRNAs are small non-coding RNAs that play a critical role in post-transcriptional control of gene expression. Recent publications of genomic sequencing data from the Chinese Hamster (CGR) and Chinese hamster ovary (CHO) cells provide new tools for the discovery of novel miRNAs in this important production system. Version 20 of the miRNA registry miRBase contains 307 mature miRNAs and 200 pr...
In this report, we have characterized the upregulation of glucose transport in two different respiration-deficient fibroblast cell cultures. We have demonstrated that glucose transport increases in respiration-deficient cells as measured by 2 deoxy D-glucose transport and is readily observed in both the WG750 human and G14 Chinese hamster fibroblast respiration-deficient cell lines when compare...
We first carried out microscopic observation of the intramural nerves of hamster and mouse gallbladders which were fixed and stained with a solution of OsO4 and ZnI2. For this microscopic observation, the guinea-pig gallbladder was used as a control. We then investigated the relationship between the motility and intramural nerves of the isolated gallbladder in both the hamster and mouse. The fo...
THE liver allograft is relatively resistant to the hyperacute rejection caused by preformed antibodies, I and in some species and strain combinations it is accepted without immunosuppression. 2•3 We have shown a similar resistance of the liver to humoral rejection after hamster to rat xenotransplantation. 4•5 Moreover. it has been shown that the liver allograft can induce tolerance to other org...
Rabbit antisera against hamster embryo cells and hamster cells which had been transformed by polyoma virus were assayed by single cell technics. Antiserum killed cells in the presence or absence of complement, and the two mechanisms of inactiva tion appear to be different. Kinetics of cell-killing by antibody and complement are described. The transformed cells studied appear to have less surfac...
Cross-species infection with transmissible spongiform encephalopathy agents may lead to subclinical infection and to adaptation of the infection to new species. This is of particular concern for the millions of people possibly exposed to bovine spongiform encephalopathy (BSE) by consumption of BSE-infected beef. Subclinical infection was studied by making 4 serial passages of hamster scrapie ag...
In recent years, the number of recombinant proteins used for therapeutic applications and industry has increased dramatically. Recombinant proteins are produced in many host organisms (microbial, insect, plant and mammalian cells). There are many factors to consider when choosing the optimal system for protein expression and purification including the mass, purity or solubility of the recombina...
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