Plant saponins have been used as additives to mitigate methane emissions originated from enteric fermentation of ruminant animals. Most of the studies however were based on in vitro techniques, and only limited studies were directly conducted on the animals. Inconsistencies of saponin effects on methane emissions have been previously observed, which might be related to their levels in rations. ...

Hansen’s disease (HD) can have a catastrophic effect on the quality of life of patients, especially when treatment is delayed. Nerve damage and its sequels are the major concern for health care providers. Early diagnosis and treatment are the only ways to mitigate the damage caused by HD. Sometimes cultural beliefs and practices become a barrier to early diagnosis and the initiation of multi dr...

INTRODUCTION Leadership is a key factor in the success of HIV prevention and treatment. Positive HIV-related outcomes are also affected by funding levels for HIV, health sector resources, disease burden and the socio-economic environment. Leadership on HIV as well as these other factors are affected by the quality of political governance of the country, which may be an overarching factor that i...

Abnormal presence of autophagic vacuoles is evident in brains of patients with Parkinson's disease (PD), in contrast to the rare detection of autophagosomes in a normal brain. However, the actual cause and pathological significance of these observations remain unknown. Here, we demonstrate a role for mitochondrial metabolism in the regulation of the autophagy-lysosomal pathway in ex vivo and in...

BACKGROUND We have previously shown that bortezomib induces a depletion of alloreactive T cells and allows the expansion of T cells with suppressive properties. In the current study, we analyzed the potential synergistic effect of bortezomib in conjunction with sirolimus in order to reduce-graft-versus-host disease without hampering graft-versus-leukemia effect in the allogeneic transplant sett...

BACKGROUND Fertility problems are an important health issue, as 10-15% of couples have difficulties conceiving. Reproductive function is thought to be compromised by lifestyle behaviours, but environmental contaminants and work-related factors are also thought to play a role. The objective of this review was to systematically summarize the available evidence concerning the influence of occupati...

Background: Acute lung injury (ALI) is among the most serious conditions characterized by an exacerbation of inflammatory response that can result from a persistent infection. Carvone chiral monoterpenoid ketone present in essential oils dill, caraway, and spearmint. It shows antioxidant, anti-inflammatory, antimicrobial effects others. In this study, anti-inflammatory protective potential mech...