11. Reivich M, Jehle J, Sokoloff L, Kety SS: Measurement of regional cerebral blood flow with "C-antipyrine in awake cats. J Appl Physiol 27: 296-300, 1969 12. Elliott KAC, Jasper HH: Physiologic salt solutions for brain surgery. J Neurosurg 6: 140-152, 1949 13. Miller JD, Stanek A, Langfitt TW: Concepts of cerebral perfusion pressure and vascular compression during intracranial hypertension. P...

The thermal unfolding curve for aa tropomyosin in which the two chains are cross-linked a t cysteine190 shows two striking features that distinguish it from that of its counterpart for non-cross-linked molecules: (1) a “pretransition” at 25-50 OC and (2) a shift in the principal transition to higher temperature, but with the same steepness. Previously, the pretransition was explained by postula...

In Autism’s False Prophets, Paul Offit, M.D., Maurice R. Hilleman Professor of Vaccinology, Professor of Pediatrics at The University of Pennsylvania, and co-inventor of a rotavirus vaccine, makes an important contribution to popular debates about the etiology and treatment of autism spectrum disorders. The book is arguably the most detailed and thorough history available of the current anti-va...

A Proud History In July 2019, the American Heart Association (AHA) Council on Basic Cardiovascular Science (BCVS) will celebrate its 20th anniversary. For this first News and Views: From the BCVS Chair for Circulation Research, I thought it would be most appropriate to provide a brief history and mission statement of the AHA BCVS Council. In 1924, 6 leading cardiologists across the nation—Drs L...

Cassava (Manihot esculenta Crantz) is a vitally important food source for many people in developing tropical countries. There are signifi cant opportunities for improving the compositional qualities and pest resistance of cassava, and modern biotechnology is expected to play an important role in these improvements. The testing and development of genetically modifi ed cassava will of course be s...

Numerical simulations of the current-voltage characteristics of an ordered two-dimensional Josephson junction array at an irrational flux quantum per plaquette are presented. The results are consistent with an scaling analysis which assumes a zero temperature vortex glass transition. The thermal correlation length exponent characterizing this transition is found to be significantly different fr...

“Let me get this right, the pilot wants to talk with me in the cockpit?” I asked the flight attendant, as the final passengers boarded the Liberia-bound jet during a refueling stop in west Africa. It was late March 2014, and a small Ebola virus disease (EVD) outbreak had been reported a few weeks earlier in Guinea. The half-read pile of malaria journal articles on my lap provided the flight cre...

November 2002 marked the 75th Scientific Sessions of the American Heart Association (AHA), a milestone that permits us to contemplate the remarkably rich heritage of the Association’s scientific meetings. The first Scientific Sessions were organized by a small group of visionary physicians at Haddon Hall in Atlantic City, New Jersey, on the afternoon of May 26, 1925 (Figure 1). The fledgling AH...

Non-invasive neuroimaging in humans permits direct investigation of the potential role for mesodiencephalic structures in consciousness. Activity in the superior colliculus can be correlated with the contents of consciousness, but it can be also identified for stimuli of which the subject is unaware; and consciousness of some types of visual stimuli may not require the superior colliculus. Merk...

Questions have been raised about Guillain-Barré syndrome (GBS) after vaccinations since the 1976 Swine flu vaccine was associated with a 7to 8-fold increased risk for GBS in the 6 weeks after vaccination, resulting in about 1 excess case of GBS per 100 000 vaccinees. There is evidence to support several possible biological mechanisms for the development of GBS, but no one has been able to deter...