The dependence of relative response factors on the carbon atom number related to naphthalene has been investigated in homologous series by using gas chromatography-mass spectrometry. Relative responses of some straight chain aliphatic n-alkanes and their halogenated derivatives (chlorine, bromine and iodine) were compared in the experiments. Linear correlations were found between the molecular ...

A new series of heterocycles incorporating antipyrine moiety were synthesized via reactions of 4-aminoantipyrine 1 with carbon disulphide then alkylation and /or chloroacetic acid to produce dithiocarbamate and rhodanine 3, 4 and 9. Multi-component reaction (MCR) of 4-aminoantipyrine with carbon disulfide and DMAD afforded rhodanine 7. The interaction of 9 with diazonium salt, DMF-DMA, nitrous ...

OBJECTIVES To synthesize new antimycobacterial and antifungal drugs that act by binding to sterol 14alpha-demethylase (14DM) and to characterize the drug-target protein interactions using computer-based molecular simulations. METHODS Different series of imidazole and triazole derivatives having an azomethine linkage to pyridine 2-carboxamidrazone were designed and synthesized. Molecular dynam...

8-Hydroxyquinoline (8HQ) compounds have been reported to possess diverse bioactivities. In recent years, drug repositioning has gained considerable attention in drug discovery and development. Herein, 8HQ (1) and its derivatives (2-9) bearing various substituents (amino, nitro, cyano and halogen) were investigated for their antimicrobial against 27 microorganisms (agar dilution method) and anti...

Vanillin is a well-known food and cosmetic additive and has antioxidant and antimutagenic properties. It has also been suggested to have antifungal activity against major human pathogenic fungi, although it is not very effective. In this study, the antifungal activities of vanillin and 33 vanillin derivatives against the human fungal pathogen Cryptococcus neoformans, the main pathogen of crypto...

Defining the interaction of newly synthesized compounds with plasma proteins is an important step in drug development process. Chromatographic techniques can be successfully used predicting biopharmaceutical and pharmacokinetic properties compounds. The aim this study to investigate isolate most molecular that affect 20 chalcones commercial (lopinavir, ritonavir, darunavir ivermectin) human ser...

1. There is no effective anti-H5N1 avian influenza agent. 2. A chemical compound— BFDBSC—can inhibit H5N1 virus infection in cell cultures, and such inhibition might be attributable to its halogenated benzoyl residues. 3. This pilot study assessed anti- H5N1 activity and toxicity of four chemical compounds with halogenated benzoyl residues in cell culture system. 4. Two compounds—FPBFDBSC and B...

A model for computing image ow in image sequences containing a very wide range of instantaneous ows is proposed. This model integrates the spatio-temporal image derivatives from multiple temporal scales to provide both reliable and accurate instantaneous ow estimates. The integration employs robust regression and automatic scale weighting in a generalized brightness constancy framework. In addi...

By-products of disinfection were tested for initiating and/or promoting activity in rat liver by using the rat liver foci bioassay. The assay uses an increased incidence of gamma-glutamyltranspeptidase-positive foci (GGT foci) as an indicator of carcinogenicity. The by-products of disinfection, including chloramine, halogenated humic acids, halogenated ethanes, halogenated acetonitriles, haloge...