A series of ethyl 2-[2-arylamino-4-(thiophen-2-yl)thiazol-5-yl] acetates (5a-5k) and ethyl 2-[2-(arylhydrazino)-4-(thiophen-2-yl)thiazol-5-yl] acetates (9a-9g) were synthesized and screened for their anti-inflammatory, analgesic, and antioxidant activities. In vivo test results showed that the compounds with halogen substitution (5c, 5g, 5h, 5i and 5j) at the para position on the 2-aryl amino g...

Chalcone derivatives have attracted increasing attention due to their numerous pharmacological activities. Changes in their structures have displayed high degree of diversity that has proven to result in a broad spectrum of biological activities. The present study highlights the synthesis of some halogen substituted chalcones 3(a-i) containing the 5-chlorothiophene moiety, their X-ray crystal s...

background: reduced time and appropriate bond strength of brackets is one of the most important aspects of orthodontic treatments. prolonged halogen light curing for bonding of brackets is undesirable, so the purpose of this study was to compare the shear bond strength of brackets bonded with halogen light and plasma arc system. materials and mehods: this was an experimental in vitro study. a t...

Sudden depletions of tropospheric ozone during spring were reported from the Arctic and also from Antarctic coastal sites. Field studies showed that those depletion events are caused by reactive halogen species, especially bromine compounds. However the source and seasonal variation of reactive halogen species is still not completely understood. There are several indications that the halogen mo...

1,2,3-Trichloropropane (TCP) is a highly toxic, recalcitrant byproduct of epichlorohydrin manufacture. Haloalkane dehalogenase (DhaA) from Rhodococcus sp. hydrolyses the carbon-halogen bond in various halogenated compounds including TCP, but with low efficiency (k (cat)/K (m )= 36 s(-1) M(-1)). A Cys176Tyr-DhaA mutant with a threefold higher catalytic efficiency for TCP dehalogenation has been ...

In this manuscript the ability of hydrogen and halogen bonding interactions, as well as metal coordination to enhance FF interactions involving fluorine substituted aromatic rings has been studied at the RI-MP2/def2-TZVPD level of theory. We have used 4-fluoropyridine, 4-fluorobenzonitrile, 3-(4-fluorophenyl)propiolonitrile and their respective meta derivatives as aromatic compounds. In additio...

Nucleophilic aromatic substitution (SNAr) reactions can provide metal-free access to synthesize monosubstituted compounds. We developed efficient SNAr conditions for p-selective of polyfluoroarenes with phenothiazine in the presence a mild base afford corresponding 10-phenylphenothiazine (PTH) derivatives. The resulting polyfluoroarene-bearing PTH derivatives were subjected second reaction gene...

Various approaches leading to mono-, diand poly-functionalized phosphonates as well as phosphoryl heterocycles were reported for the systematic study of relationship between chemical structure and biological activities of this most important class of organophosphorus compounds. Introduction Functionalization of phosphonic acid molecules opens enoi-nious possibilities of structural variation of ...