Halofantrine hydrochloride (halfan) was administered via oral route to matured female wistar rats weighing 180-200 g. The Wistar rats were randomly selected and divided into six groups of four rats each, making a total of twenty four rats and coded A1, A2, A3, B1, B2 and B3. Groups A3 and B3 were used as controls. Three consecutive doses of 1 mg/100 g halfan each were administered to group A1 a...

With the rising prevalence of obesity, non-alcoholic fatty liver disease (NAFLD) now affects 20–25% global population. NAFLD, a progressive condition associated with oxidative stress, can result in cirrhosis and cancer 10% 3% patients suffering respectively. Therapeutic options are currently limited, emphasizing need for novel treatments. In this study, we examined potential activating transcri...

Abstract Development of resistance by malaria parasites to conventional antimalarial drugs has rejuvenated the exploration herbal medicine as alternatives. Also, increasing rate use remedies in combination with (both synthetic and semi-synthetic) inspired researchers validate their herb-drug interaction effects. This review evaluated outcomes between drugs. With aid electronic databases, Pubmed...

When U.S. troops first encountered drug resistant malaria during the Vietnam war, the United States Army responded by establishing a malaria drug research program. In 1988, the Walter Reed Army Institute of Research developed mefloquine (WR 149240) and halofantrine (WR 171669). Actually in association with SmithKline Beecham, the WRAIR is developing tafenoquine (WR 238605), an analogue of prima...