To test the hypothesis that Na+ transport in human bronchial epithelial (HBE) cells is regulated by a protease-mediated mechanism, we investigated the effects of BAY 39-9437, a recombinant Kunitz-type serine protease inhibitor, on amiloride-sensitive short-circuit current of normal [non-cystic fibrosis (CF) cells] and CF HBE cells. Mucosal treatment of non-CF and CF HBE cells with BAY 39-9437 d...

Questions have been raised about the effects human activity in Hawai‘ian bays has on dolphins. Concerns about the effects of this activity have led the National Marine Fisheries Service to begin the process of enacting regulations to reduce the impacts of swimmers and vessels on Hawaiian spinner dolphins (Stenella longirostris). One step in evaluating potential effects is to determine if dolphi...

Port Phillip Bay, Australia, is a large semi-closed bay with over four million people living in its catchment basin. The Bay receives waters from the Yarra River which drains the city of Melbourne, as well as receiving the discharges of sewage treatment plants and petrochemical and agricultural chemicals. A 1999 study demonstrated that fish inhabiting Port Phillip Bay showed signs of effects re...

this paper uses a psopc model based non-destructive damage identification procedure using frequency and modal data. the objective function formulation for the minimization problem is based on the frequency changes. the method is demonstrated by using a cantilever beam, four-bay plane truss and two-bay two-story plane frame with different scenarios. in this study, the modal data are provided nume...

Department of Pharmacy, Island Health, 1952 Bay St, Victoria, BC V8R 1J8, Canada; Department of Laboratory Medicine, Medical Microbiology Division, Island Health, 1952 Bay St, Victoria, BC V8R 1J8, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, G227–2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada; Department of Infectious Diseases, Island Health, 1952...

Not Mediated by Phosphodiesterase 5 Inhibition To the Editor: A major conclusion of the recent publication of Mullershausen et al1 is that “the physiological effects of BAY 41-2272 . . . are due to the synergism of sensitization of NO-sensitive GC [guanylate cyclase] and inhibition of PDE5.” This conclusion is based on the authors’ finding that BAY 41-2272 stimulates sGC and inhibits human PDE5...

Not Mediated by Phosphodiesterase 5 Inhibition To the Editor: A major conclusion of the recent publication of Mullershausen et al1 is that “the physiological effects of BAY 41-2272 . . . are due to the synergism of sensitization of NO-sensitive GC [guanylate cyclase] and inhibition of PDE5.” This conclusion is based on the authors’ finding that BAY 41-2272 stimulates sGC and inhibits human PDE5...

This paper uses a PSOPC model based non-destructive damage identification procedure using frequency and modal data. The objective function formulation for the minimization problem is based on the frequency changes. The method is demonstrated by using a cantilever beam, four-bay plane truss and two-bay two-story plane frame with different scenarios. In this study, the modal data are provided nume...

desalination plants are potentially capable of having impacts on coastal marine environments due to the production of wastewater with high concentrations of salts (brine discharge) and some heavy metals. the aim of this study was to examine the concentration of accumulated metals (ni, cu, cd, fe, zn, pb) in the sediments near the brine discharge point in the chabahar bay. twenty one sediment sa...

the catch composition of the bottom trawl fishery along the coasts of karataş was evaluated in the 2002-2003 fishing season. a total of 110 species were registered, the fishes showed the highest diversity (90 species) followed by 15 crustaceans species and 5 species of cephalopods. the highest catch per unit effort (cpue) value (66.8 kg h -1 ) was recorded in september when the fishing season w...