Palmitoylation is a key post-translational modification mediated by a family of DHHC-containing palmitoyl acyl-transferases (PATs). Unlike other lipid modifications, palmitoylation is reversible and thus often regulates dynamic protein interactions. We find that the mouse hair loss mutant, depilated, (dep) is due to a single amino acid deletion in the PAT, Zdhhc21, resulting in protein mislocal...

www.aafp.org/afp AMERICAN FAMILY PHYSICIAN 1907 follicular canal, dehydrate, and form the growing shaft. The visible hair shaft is composed of an outer cuticle, the cortex and, sometimes, a core of compact, keratinized cells, all of which are made of protein. Hairs that are in the anagen phase during removal are more sensitive to the various treatment modalities than hairs in the telogen phase....

BACKGROUND Dermoscopy is a diagnostic tool that can reveal morphological structures not visible upon clinical examination. HYPOTHESIS/OBJECTIVES To assess the usefulness and applicability of dermoscopy for the examination of healthy cat skin. ANIMALS Twenty-one domestic short-haired cats from a feline rescue association. METHODS Four regions (head, dorsal neck, sacral and abdominal region...

The 14-3-3σ (Stratifin; Sfn) is a cell cycle regulator intimately involved in the program of epithelial keratinization. 14-3-3σ is unique in that it is expressed primarily in epithelial cells and is frequently silenced in epithelial cancers. Despite its well-documented role as a cell cycle regulator and as a tumor suppressor, the function of 14-3-3σ in the intricate balance of proliferation and...

OBJECTIVE To examine the clinical, histological, and immunohistological effects of flashlamp photoepilation. DESIGN Nonrandomized control trial with blinded histological study and follow-up of 1 to 20 months. SETTING Private academic practice. SUBJECTS Sixty-seven subjects (10 males and 57 females) with areas of excess body hair. INTERVENTIONS Single (9 subjects) or multiple (58 subject...

Abstract This paper presents the modelling, design, fabrication and characterization of flow sensors based on the wind-receptor hairs of crickets. Cricket sensory hairs are highly sensitive to drag-forces exerted on the hair shaft. Artificial sensory hairs have been realized in SU-8 on suspended SixNy membranes. The movement of the membranes is detected capacitively. Capacitance versus voltage,...

In this paper brief observations are made on the principal dimensions, cross-sectional shapes and cuticular scale patterns of hairs of the Tasmanian monotremes and marsupials. The observations on the cuticular scale patterns alone, without considering other elements of the hair shaft, are of only limited value in a comparative study of marsupial hairs. However, it is suggested that a detailed m...

IMPORTANCE Recent studies have reported "comma hairs" as a typical dermoscopic feature of tinea capitis observed at low magnification (×10). The aim of this study was to evaluate the dermoscopic aspects of tinea capitis at high magnification (×150) and its diagnostic role. OBSERVATIONS Five children (2 boys and 3 girls; aged 4-10 years) with multiple scaly patches of alopecia underwent scalp ...