نتایج جستجو برای: h5 index

تعداد نتایج: 398069  

Journal: :RNA 2006
Guohua Zhang Jiuchun Zhang Anna T George Tilman Baumstark Anne E Simon

Synthesis of wild-type levels of turnip crinkle virus (TCV)-associated satC complementary strands by purified, recombinant TCV RNA-dependent RNA polymerase (RdRp) in vitro was previously determined to require 3' end pairing to the large symmetrical internal loop of a phylogenetically conserved hairpin (H5) located upstream from the hairpin core promoter. However, wild-type satC transcripts, whi...

Journal: :The Biochemical journal 1984
E Kotthaus W H Strätling

We have studied the HClO4-solubility of histones H1 and H5 in hen erythrocyte nuclei after treatment with the cross-linker dimethyl 3,3'-dithiobispropionimidate (DTPI). The amount of acid-soluble, non-cross-linked, H1 and H5 histones was drastically decreased, and that of acid-soluble H1/H5 histone dimers went through an optimum as the DTPI concentration was raised. Incubation of the HClO4-inso...

Journal: :Journal of Synthetic Organic Chemistry, Japan 1984

Journal: :Vaccine 2006
Ma Mingxiao Jin Ningyi Wang Zhenguo Wang Ruilin Fei Dongliang Zheng Min Yin Gefen Li Chang Jia Leili Jin Kuoshi Zhang Yingjiu

cDNAs of the HA genes of subtype H5N1 AIV were fused to form a single open reading frame, designated H5HA-H7HA. The H5HA-H7HA cDNA and chicken Interleukin-18 (IL18) were inserted into the fowlpox virus (FPV) expression vector pUTA-16-LacZ to produce pUTAL-H5-H7-IL18. cDNA of H5N1 AIV HA was inserted into the FPV expression vector pUTA2 to create the recombinant expression plasmid pUTA2-H5. Plas...

2012
Peng Yang Chunna Ma Weixian Shi Shujuan Cui Guilan Lu Xiaomin Peng Daitao Zhang Yimeng Liu Huijie Liang Yi Zhang Li Zhang Holly Seale Quanyi Wang

The continued spread of highly pathogenic avian influenza (HPAI) viruses of H5 and H7 subtypes and low pathogenic avian influenza (LPAI) viruses of H5, H7 and H9 subtypes in birds and the subsequent infections in humans pose an ongoing pandemic threat. It has been proposed that poultry workers are at higher risk of exposure to HPAI or LPAI viruses and subsequently infection due to their repeate...

Journal: :Molecular bioSystems 2014
Shi Jin Dong Pan Xiao Zha Xianghui Yu Yuqing Wu Yongjiang Liu Fei Yin Xiaojiang S Chen

The mono-site mutations of the absolutely conserved residues, (464)LGR(466), in the α-helix 5 (h5) of HPV16 L1 completely disrupted the pentamer formation. The implication of this finding is the potential usage of a h5-like peptide as the reagent to interfere with the pentamer formation and stability as an anti-HPV reagent.

2013
Leonardo Romorini Diego Ariel Riva Carolina Blüguermann Guillermo Agustin Videla Richardson Maria Elida Scassa Gustavo Emilio Sevlever Santiago Gabriel Miriuka

Human embryonic stem cells (hESCs) are self-renewing pluripotent cells that can differentiate into specialized cells and hold great promise as models for human development and disease studies, cell-replacement therapies, drug discovery and in vitro cytotoxicity tests. The culture and differentiation of these cells are both complex and expensive, so it is essential to extreme aseptic conditions....

Journal: :The Journal of pharmacology and experimental therapeutics 2014
Kenji Maeda Haruhiko Sugino Hitomi Akazawa Naoki Amada Jun Shimada Takashi Futamura Hiroshi Yamashita Nobuaki Ito Robert D McQuade Arne Mørk Alan L Pehrson Morten Hentzer Vibeke Nielsen Christoffer Bundgaard Jørn Arnt Tine Bryan Stensbøl Tetsuro Kikuchi

Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel drug candidate in clinical development for psychiatric disorders with high affinity for serotonin, dopamine, and noradrenaline receptors. In particular, it bound with high affinity (Ki < 1 nM) to human serotonin 1A (h5-HT1A)-, h5-HT2A-, long form of human D2 (hD2L)-, hα1B-, and hα2C-adre...

Journal: :Clinical and vaccine immunology : CVI 2007
Qigai He Sumathy Velumani Qingyun Du Chee Wee Lim Fook Kheong Ng Ruben Donis Jimmy Kwang

The unprecedented spread of highly pathogenic avian influenza virus subtype H5N1 in Asia and Europe is threatening animals and public health systems. Effective diagnosis and control management are needed to control the disease. To this end, we developed a panel of monoclonal antibodies (MAbs) against the H5N1 avian influenza virus (AIV) and implemented an antigen-capture enzyme-linked immunosor...

Journal: :Influenza and other respiratory viruses 2016
Meng Li Zhixun Xie Zhiqin Xie Jiabo Liu Liji Xie Xianwen Deng Sisi Luo Qing Fan Li Huang Jiaoling Huang Yanfang Zhang Tingting Zeng Jiaxun Feng

OBJECTIVES In order to develop a multiplex RT-PCR assay using the GeXP analyser for the simultaneous detection of four different NA serotypes of H5-subtype AIVs, effective to control and reduce H5 subtype of avian influenza outbreak. DESIGN Six pairs of primers were designed using conserved and specific sequences of the AIV subtypes H5, N1, N2, N6 and N8 in GenBank. Each gene-specific primer ...

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