AbstractBackground Electroconvulsive therapy (ECT) has been shown to induce broadly distributed cortical and subcortical volume increases, more prominently in the amygdala hippocampus. Structural changes after one ECT session long-term have understudied. Objective The aim of this study was describe short-term induced regions by ECT. Methods brain data were ac...

AbstractObjective To explore the course of quality life (QoL) and possible resident-related predictors associated with this in institutionalized people young-onset dementia (YOD). Design An observational longitudinal study. Setting Participants A total 278 residents YOD were recruited from 13 special care units Netherlands. Methods Secondary analyses...

AbstractBackground Low serum magnesium levels predict cardiovascular and all-cause mortality in patients with typ 2 diabetes. Setting Outpatient clinic of obesity central hospital. Objectives To assess long-term alterations circulating status after Roux-en-Y gastric bypass (RYGB) surgery associations remission type diabetes (T2D). Methods Retrospecti...

AbstractBackground and aims We aimed to validate a nurse-led process using electronic health records identify those at risk of familial hypercholesterolaemia (FH) for genetic diagnosis in primary care. Methods Those FH were identified searches developed refined locally implemented care by trained nurse; they invited further assessment testing if indicated. Family memb...

Background: The percentage of adults achieving hemoglobin A1c goals less than 7% remains a challenge. study objective was to evaluate effects multidisciplinary approach on behavioral outcomes and mean change in immediate start (intervention) versus 6-month delay (control) groups at 6 months. Methods: assessed 111 patients recruited from safety-net primary care clinic with phar...

AbstractBackground Hepatocellular carcinoma (HCC) is frequently diagnosed as multinodular. This study aims to assess prognostic factors for survival and identify patients with multiple HCC who may benefit from surgery beyond the Barcelona Clinic Liver Cancer classification indications. Methods retrospective included all consecutive 4 Italian tertiary centers receiving...

Abstract Importance Repurposing Ivermectin, a known anti-parasitic agent, for treating COVID-19 has demonstrated positive results in several studies. We aim to evaluate the benefit and risk of Ivermectin COVID-19. Methods conducted systematic search full-text manuscripts published from February 1, 2020, August 15th, 2021 focusing on therapy against The primary outcome...

AbstractObjectives Maintenance of independence is a challenge for nursing home residents whose pain often substantial. The objective this study was to explore the relationship between perception and care dependency in population Dutch residents. Design Prospective cohort study. Setting participants aged 65 or older, excluding with severe cognitive impairment....

Nucleosome assembly following DNA replication and gene transcription is important to maintain genome stability and epigenetic information. Newly synthesized histones H3-H4 first bind histone chaperone Asf1 and are then transferred to other chaperones for nucleosome assembly. However, it is unknown how H3-H4 is transferred from the Asf1-H3-H4 complex to other chaperones because Asf1 binds H3-H4 ...