Hydrogen sulfide (H2S), a gasotransmitter, is endogenously formed from Lcysteine by certain enzymes including cystathionineγlyase (CSE) in the mammalian body. H2S sensitizes Cav3.2 Ttype calcium channels, leading to excitation of sensory neurons followed by somatic hyperalgesia in rats and mice. The enhanced activity of the H2S/Cav3.2 system is involved in the neuropathic pain/hyperalgesia indu...

gases such as no and co play important roles both in normal physiology and in disease. in recent years, interest has been directed towards other naturally occurring gases, notably h 2 s, which is produced in body by three enzymes namely cbs (cystathionine beta synthase), cse (cystathionine gamma lyase) and mst (3-mercaptopyruvate sulfurtransferase), present in mitochondria and/or cytosols where...

Reactive sulfur species (RSS) such as H2S, HS•, H2Sn, (n = 2-7) and HS2•- are chemically similar to H2O and the reactive oxygen species (ROS) HO•, H2O2, O2•- and act on common biological effectors. RSS were present in evolution long before ROS, and because both are metabolized by catalase it has been suggested that "antioxidant" enzymes originally evolved to regulate RSS and may continue to do ...

Hydrogen sulfide (H2S) plays an important role in human physiology, exerting vasodilatory, neuromodulatory and anti-inflammatory effects. H2S has been implicated in the mechanism of gastrointestinal integrity but whether this gaseous mediator can affect hemorrhagic lesions induced by stress has been little elucidated. We studied the effect of the H2S precursor L-cysteine, H2S-donor NaHS, the H2...

Hydrogen sulfide accumulated under a cover film in a landfill site was treated for 7 months by a full-scale biofilter packed with polyurethane foam cubes. Sampling ports were set along the biofilter bed to investigate H2S removal and microbial characteristics in the biofilter. The H2S was removed effectively by the biofilter, and over 90% removal efficiency was achieved in steady state. Average...

Hydrogen sulfide (H2S) is the third biological gasotransmitter, and in animals, it affects many physiological processes by modulating ion channels. H2S has been reported to protect plants from oxidative stress in diverse physiological responses. H2S closes stomata, but the underlying mechanism remains elusive. Here, we report the selective inactivation of current carried by inward-rectifying K(...

Hydrogen sulfide (H2S) has been revealed to be a signal molecule with second messenger action in the somatic cells of many tissues, including the reproductive tract. The aim of this study was to address how exogenous H2S acts on the meiotic maturation of porcine oocytes, including key maturation factors such as MPF and MAPK, and cumulus expansion intensity of cumulus-oocyte complexes. We observ...

H2S is a key chemical mediator that exerts a vital role in diverse physiological and pathological processes. However, in vivo tracking of endogenous H2S generation still remains difficult due to the lack of reliable analytical methods. Herein, we present the first example of activatable photoacoustic probes for real-time imaging of H2S in living mice through the full utilization of the superior...

21 Hydrogen sulfide (H2S) is the third endogenous signaling gasotransmitter, following 22 nitric oxide and carbon monoxide. It is physiologically generated by cystathionine-γ-lyase, 23 cystathionine-β-synthase, and 3-mercaptopyruvate sulfurtransferase. H2S has been gaining 24 increasing attention as an important endogenous signaling molecule because of its 25 significant effects on the cardiova...

BACKGROUND H2S is a novel type of endogenous neural regulatory factor and gaseous mediator. Exogenous H2S can increase heroin-induced learning and memory damage in rat and alleviates heroin-induced rat hippocampus damage through antioxidant and anti-apoptosis effects. OBJECTIVE Aim of this study was to identify whether hydrogen sulfide (H2S) protects heroin withdrawal rat is related with aden...