1. The intradermal injection of H. influenzae in the abdominal wall of rabbits induces inflammation, frequently combined with a central pustule. The corresponding injection of H. pertussis causes a bluish violet discoloration of the skin area involved which undergoes slight hemorrhagic necrotic changes within a few days. 2. The intravenous injection of living H. influenzae, 24 hours after the i...

The minimal inhibitory concentration of cefaclor, cephalexin, cephradine, cefamandole, cephalothin, cephapirin, cefazolin, ampicillin, chloramphenicol, and tetracycline for inhibition of 198 freshly isolated clinical strains of Haemophilus species (23 H. influenzae type b, 157 H. influenzae non-type b, 14 H. parainfluenzae, and 4 H. aphrophilus) was determined simultaneously by a slightly modif...

Sixty-three strains of Haemophilus species, 38 of which were beta-lactamase producers (37 H. influenzae type b, 1 H. parainfluenzae) and 25 of which were beta-lactamase negative (20 H. influenzae, 5 H. parainfluenzae), were tested for susceptibility to cefoxitin, moxalactam (LY127935) (Lilly), cefsulodin (CGP 7174 E, Ciba), and cefoperazone (T 1551, Pfizer). Cefsulodin was relatively inactive a...

BACKGROUND People affected with sickle cell disease are at high risk of infection from Haemophilus influenzae type b. Before the implementation of Haemophilus influenzae type b conjugate vaccination in high-income countries, this was responsible for a high mortality rate in children under five years of age. In African countries, where coverage of this vaccination is still extremely low, Haemoph...

The chemical structure and biologic function of the lipid A portion of lipopolysaccharide are not identical among gram-negative bacteria. This study indicates that antigenically heterogeneous lipid A exists among strains of Haemophilus influenzae. An immunoglobulin G3 murine monoclonal antibody, 3D2, produced against a nontypable H. influenzae strain 3524 has specificity for a site on the lipid...

OBJECTIVE To investigate the epidemiology of invasive disease due to Haemophilus influenzae type b, the clones responsible, and the antibiotic resistance of the isolates. DESIGN Prospective population based analysis of clinical and epidemiological data collected for Gwynedd during 1980-90 and in the whole of Wales during 1988-90. SETTING 19 hospitals in Wales; all medical microbiology labor...

OBJECTIVES To assess the immunogenicity of vaccines for infants and to investigate whether the incidence of reactogenicity is reduced after each immunisation dose using needles of varying lengths and gauges. DESIGN Randomised controlled trial. SETTING 18 general practices within two UK primary care trusts. PARTICIPANTS 696 healthy infants vaccinated at 2, 3, and 4 months of age, with foll...

philus influenzae. Document no. WHO/CDS/CSR/EDC/99.7. Geneva: World Health Organization; 1999. 2. Cheesbrough M. Medical laboratory manual for tropical countries, Vol II. London: Butterworth-Heinemann; 1985. p.160–74. 3. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility testing. Approved standard, 7th ed. Document M2-A7. Wayne (PA)...

BACKGROUND Childhood bacterial meningitis is severe and largely preventable by vaccination. Few data on childhood bacterial meningitis in Northeast and Central Asia exist. Our aim was to determine the incidence and etiology of childhood bacterial meningitis in Ulaanbaatar, Mongolia. METHODS We conducted prospective, population-based, active hospital surveillance for clinical meningitis in chi...