نتایج جستجو برای: gv saft msa
تعداد نتایج: 5013 فیلتر نتایج به سال:
To elucidate molecular bases of multiple system atrophy (MSA), we first focused on recently identified MSA multiplex families. Though linkage analyses followed by whole genome resequencing, we have identified a causative gene, COQ2, for MSA. We then conducted comprehensive nucleotide sequence analysis of COQ2 of sporadic MSA cases and controls, and found that functionally deleterious COQ2 varia...
In this work, the soft statistical associating fluid theory (soft-SAFT) equation of state (EoS) has been used to provide an accurate thermodynamic characterization of the pyridinium-based family of ionic liquids (ILs) with the bis(trifluoromethylsulfonyl)imide anion [NTf(2)](-). On the basis of recent molecular simulation studies for this family, a simple molecular model was proposed within the...
Multiple system atrophy (MSA) is a neurodegenerative disease characterized clinically by any combination of autonomic, cerebellar, and extrapyramidal symptoms. Autonomic symptoms are usually severe, and urinary symptoms are one of the cardinal features of MSA. Bowel dysfunction and sexual dysfunction are also common in MSA. Quality of life (QOL) in patients with MSA is severely impaired by the ...
The clinical diagnosis of multiple system atrophy (MSA) is fraught with difficulty and there are no pathognomonic features to discriminate the parkinsonian variant (MSA-P) from Parkinson's disease (PD). Besides the poor response to levodopa, and the additional presence of pyramidal or cerebellar signs (ataxia) or autonomic failure as major diagnostic criteria, certain other clinical features kn...
Multiple system atrophy (MSA) is a rapidly-progressive neurodegenerative disease characterized by parkinsonism, cerebellar ataxia and autonomic failure. A pathological hallmark of MSA is the presence of α-synuclein deposits in oligodendrocytes, the myelin-producing support cells of the brain. Brain pathology and in vitro studies indicate that myelin instability may be an early event in the path...
BACKGROUND Griseoviridin (GV) and viridogrisein (VG, also referred as etamycin), both biosynthesized by a distinct 105 kb biosynthetic gene cluster (BGC) in Streptomyces griseoviridis NRRL 2427, are a pair of synergistic streptogramin antibiotics and very important in treating infections of many multi-drug resistant microorganisms. Three transporter genes, sgvT1-T3 have been discovered within t...
Abstract. Atmospheric organic acids (OAs) are expected to enhance methanesulfonic acid (MSA)-driven new particle formation (NPF). However, the exact role of OAs in MSA-driven NPF remains unclear. Here, we employed a two-step strategy probe MSA–methylamine (MA) NPF. Initially, evaluated enhancing potential 12 commonly detected ternary MA–MSA–OA cluster by considering free energies (MSA)1(MA)1(OA...
یکی از فرآیندهایی که جهت استخراج آسفالتین از نفت خام به کار میرود ، فرآیند استخراج آسفالتین با حلال های سبک آلکانی می باشد. در این مقاله به بررسی پدیده رسوب آسفالتین در نفت خام در حین فرآیند تیتراسیون نفت با حلالهای آلکانی پرداخته شده است. بدین منظور پس از معرفی مدلهای موجود ترمودینامیکی، مدلسازی ترمودینامیکی رسوب آسفالتین ناشی از فرآیند تیتراسیون نفت با حلالهای آلکانی توسط سه مدل ترمودینامیکی ...
BACKGROUND The role of glycemic variability (GV) in development of cardiovascular diseases remains controversial, and factors that determine glucose fluctuation in patients with diabetes are unknown. We investigated relationships between GV indices, kinds of oral hypoglycemic agents (OHAs), and cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM). METHODS We analyzed 2...
This paper analyzes the problem of the spectral enhancement technique using global variance (GV) in HMM-based speech synthesis. In the conventional GV-based parameter generation, spectral enhancement with variance compensation is achieved by considering a GV pdf with fixed parameters for every output utterances through the generation process. Although the spectral peaks of the generated traject...
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