• natural hosts: wild mice [1], laboratory mice, [2] [3] [4], water , bank and meadow voles (family Microtinae) [5] [6] • positive serological reactions in laboratory rats [7] [8]; virus might be related to TMEV -virus, only one report on clinical signs and lesions in rats (MHG-strain) [9], positive serological findings may indicate the presence of a yet uncharacterised virus (?rat cardiovirus?...

Background: Several therapeutic effects including anti-asthma and dyspnea have been described for Plantago lanceolata. In the present study the antitussive effect of this plant was evaluated. Methods: The antitussive effects of aerosols of two different concentrations of Soxhlet and macerated ethanolic extracts, codeine and saline were tested by counting the number of coughs produced due to aer...

The aim in this study was to examine protein synthesis in the liver tissue under the effect of exogenous electric fields applied in different intensitities and directions. Sixty male white guinea pigs, weighing 350-400 g were used for the study. The E field of 1.9 kV/m obtained from a DC (Direct Current) power supply with 300 V was applied in vertical direction to 10 guinea pigs, and in horizon...

BACKGROUND Effective treatment for drug-susceptible tuberculosis (TB) rapidly renders patients non-infectious, long before conversion of sputum acid-fast smear or culture to negative. Multidrug-resistant TB (MDR-TB) patients on treatment are currently assumed to remain infectious for months. While the resources required for prolonged hospitalization are a barrier to the scale-up of MDR-TB treat...

Antigenic variants were derived from a mutagen-treated, apparently nonimmunogenic fibrosarcoma of strain 2 guinea pigs. Fibrosarcoma line 107C3, originally induced by exposure of fetal cells to a chemical mutagen, was treated in vitro with the same mutagen. Cells that survived mutagen treatment were cloned, and the clones were tested for growth in soft agar, in conventional and immunosuppressed...

It is well established that the nutritional status of the host affects resistance to disease. The impact of dietary lipids on experimental pulmonary infection with mycobacteria has not been investigated. Therefore, the purpose of this study was to determine the role of dietary (n-3) and (n-6) fatty acids on immunity and resistance to aerosol infection with virulent Mycobacterium tuberculosis in...

BACKGROUND Exhaled nitric oxide (ENO) is elevated in bronchial asthma patients, and inhaled corticosteroid therapy lowers the elevated ENO levels in such patients. ENO appears to be an inflammatory marker, but its role in the pathophysiology of cough remains unclear. This study aimed to elucidate the relationship between NO and increased cough reflex sensitivity induced by allergic airway react...

1. Cholesterol, administered intraperitoneally, in these experiments definitely prolonged the lives of tuberculous guinea pigs when the infection was of an acute type produced by inoculation with a small dose of very virulent human type organisms. 2. Intraperitoneally administered cholesterol did not definitely prolong the lives of tuberculous guinea pigs when the infection was of the chronic t...

UNLABELLED To understand how the DNA answers to external agents such as cisplatin may be relevant to the diagnosis and treatment of hearing disorders caused by the administration of such drug. OBJECTIVES To investigate the cisplatin influence on the cochlea and DNA of guinea pigs. MATERIAL AND METHODS Experimental study carried out with 12 guinea pigs (Cavia porcellus). The inclusion criter...

Protein malnutrition leads to multiple detrimental alterations of host immune responses to mycobacterial infection. In this study, we demonstrated that splenocytes from low-protein (LP) guinea pigs vaccinated 6 weeks previously with attenuated Mycobacterium tuberculosis H37Ra failed to control the accumulation of virulent M. tuberculosis H37Rv in cocultured autologous peritoneal macrophages, de...